Chemical biology news and research from across RSC Publishing.
Contents list for Highlights in Chemical Biology: Research Articles, issue 11, 2009
Editorial
The discovery and development of the green fluorescent protein, GFP
Jeremy K. M. Sanders and Sophie E. Jackson,
Chem. Soc. Rev., 2009, 38, 2821
DOI: 10.1039/b917331p
Reviews
The aminocoumarins: biosynthesis and biology
Lutz Heide,
Nat. Prod. Rep., 2009, 26, 1241
DOI: 10.1039/b808333a
An update on lignans: natural products and synthesis
Jian-Yu Pan, Shi-Lin Chen, Mei-Hua Yang, Jun Wu, Jari Sinkkonen and Kun Zou,
Nat. Prod. Rep., 2009, 26, 1251
DOI: 10.1039/b910940d
The repertoire of glycan determinants in the human glycome
Richard D. Cummings,
Mol. BioSyst., 2009, 5, 1087
DOI: 10.1039/b907931a
Enhanced HTML article available
Receptor tyrosine kinase signaling: a view from quantitative proteomics
Joern Dengjel, Irina Kratchmarova and Blagoy Blagoev,
Mol. BioSyst., 2009, 5, 1112
DOI: 10.1039/b909534a Enhanced HTML article available
Fluorine—a new element in the design of membrane-active peptides
E. Neil G. Marsh, Benjamin C. Buer and Ayyalusamy Ramamoorthy,
Mol. BioSyst., 2009, 5, 1143
DOI: 10.1039/b909864j Enhanced HTML article available
Understanding apoptosis by systems biology approaches
Inna N. Lavrik, Roland Eils, Nicolai Fricker, Carina Pforr and Peter H. Krammer,
Mol. BioSyst., 2009, 5, 1105
DOI: 10.1039/b905129p Enhanced HTML article available
Phosphoproteomics—finally fulfilling the promise?
Lindsay D. Rogers and Leonard J. Foster,
Mol. BioSyst., 2009, 5, 1122
DOI: 10.1039/b905580k Enhanced HTML article available
Mitochondrial proteomics and its application in biomedical research
Cristina Ruiz-Romero and Francisco J. Blanco,
Mol. BioSyst., 2009, 5, 1130
DOI: 10.1039/b906296n Enhanced HTML article available
Critical Reviews
Microfluidic sample preparation: cell lysis and nucleic acid purification
Jungkyu Kim, Michael Johnson, Parker Hill and Bruce K. Gale,
Integr. Biol., 2009, 1, 574
DOI: 10.1039/b905844c Enhanced HTML article available
The fluorescent protein palette: tools for cellular imaging
Richard N. Day and Michael W. Davidson,
Chem. Soc. Rev., 2009, 38, 2887
DOI: 10.1039/b901966a
Excited state reactions in fluorescent proteins
Stephen R. Meech,
Chem. Soc. Rev., 2009, 38, 2922
DOI: 10.1039/b820168b
Photoreactions and dynamics of the green fluorescent protein
Jasper J. van Thor,
Chem. Soc. Rev., 2009, 38, 2935
DOI: 10.1039/b820275n
The folding, stability and conformational dynamics of 
-barrel fluorescent proteins
Shang-Te Danny Hsu, Georg Blaser and Sophie E. Jackson,
Chem. Soc. Rev., 2009, 38, 2951
DOI: 10.1039/b908170b
Highlights
GFP: from jellyfish to the Nobel prize and beyond
Marc Zimmer,
Chem. Soc. Rev., 2009, 38, 2823
DOI: 10.1039/b904023d
Electrodes for integral membrane enzymes
Lars J. C. Jeuken,
Nat. Prod. Rep., 2009, 26, 1234
DOI: 10.1039/b903252e
Technical Note
Fabrication of reversibly adhesive fluidic devices using magnetism
Marjan Rafat, Danielle R. Raad, Amy C. Rowat and Debra T. Auguste,
Lab Chip, 2009, 9, 3016
DOI: 10.1039/b907957b
Tutorial Reviews
Visualization of molecular interactions using bimolecular fluorescence complementation analysis: Characteristics of protein fragment complementation
Tom K. Kerppola,
Chem. Soc. Rev., 2009, 38, 2876
DOI: 10.1039/b909638h
The structure and function of fluorescent proteins
Vedangi Sample, Robert H. Newman and Jin Zhang,
Chem. Soc. Rev., 2009, 38, 2852
DOI: 10.1039/b913033k
FRET and mechanobiology
Yingxiao Wang and Ning Wang,
Integr. Biol., 2009, 1, 565
DOI: 10.1039/b913093b Enhanced HTML article available
The photochemistry of fluorescent proteins: implications for their biological applications
Harriet E. Seward and Clive R. Bagshaw,
Chem. Soc. Rev., 2009, 38, 2842
DOI: 10.1039/b901355p
Green fluorescent protein: structure, folding and chromophore maturation
Timothy D. Craggs,
Chem. Soc. Rev., 2009, 38, 2865
DOI: 10.1039/b903641p
Genetically encoded biosensors based on engineered fluorescent proteins
Wolf B. Frommer, Michael W. Davidson and Robert E. Campbell,
Chem. Soc. Rev., 2009, 38, 2833
DOI: 10.1039/b907749a
Viewpoint
Cutting edge: Electronic counting of white blood cells
Daniel Irimia,
Lab Chip, 2009, 9, 2875
DOI: 10.1039/b917138j
Communications
Highly efficient cell adhesion on beads functionalized with clustered peptide ligands
Stéphanie Foillard, Pascal Dumy and Didier Boturyn,
Org. Biomol. Chem., 2009, 7, 4159
DOI: 10.1039/b911440h
Synthesis and biological evaluation of the first pentafluorosulfanyl analogs of mefloquine
Peter Wipf, Tingting Mo, Steven J. Geib, Diana Caridha, Geoffrey S. Dow, Lucia Gerena, Norma Roncal and Erin E. Milner,
Org. Biomol. Chem., 2009, 7, 4163
DOI: 10.1039/b911483a
Bypassing stereoselectivity in the early steps of alkaloid biosynthesis
Peter Bernhardt, Nancy Yerkes and Sarah E. O'Connor,
Org. Biomol. Chem., 2009, 7, 4166
DOI: 10.1039/b916027m
Convenient modular method for affinity labeling (MoAL method) based on a catalytic amidation
Munetaka Kunishima, Shuichi Nakanishi, Jin Nishida, Hiroyuki Tanaka, Daiki Morisaki, Kazuhito Hioki and Hiroshi Nomoto,
Chem. Commun., 2009, 5597
DOI: 10.1039/b912908a
Automated high-throughput cell microsurgery on-chip
Kwanghun Chung and Hang Lu,
Lab Chip, 2009, 9, 2764
DOI: 10.1039/b910703g
Time-resolved lanthanide luminescence for lab-on-a-chip detection of biomarkers on cancerous tissues
Bo Song, Venkataragavalu Sivagnanam, Caroline D. B. Vandevyver, Ilkka Hemmilä, Hans-Anton Lehr, Martin A. M. Gijs and Jean-Claude G. Bünzli,
Analyst, 2009, 134, 1991
DOI: 10.1039/b911301k
Site-specific covalent labeling of His-tag fused proteins with a reactive Ni(II)–NTA probe
Sho-hei Uchinomiya, Hiroshi Nonaka, Sho-hei Fujishima, Shinya Tsukiji, Akio Ojida and Itaru Hamachi,
Chem. Commun., 2009, 5880
DOI: 10.1039/b912025d Enhanced HTML article available
Saturation transfer difference NMR reveals functionally essential kinetic differences for a sugar-binding repressor protein
Ignacio Pérez-Victoria, Sebastian Kemper, Mitul K. Patel, John M. Edwards, James C. Errey, Lucia F. Primavesi, Matthew J. Paul, Timothy D. W. Claridge and Benjamin G. Davis,
Chem. Commun., 2009, 5862
DOI: 10.1039/b913489a Enhanced HTML article available
High-throughput ESI-MS analysis of binding between the Bombyx mori pheromone-binding protein BmorPBP1, its pheromone components and some analogues
Antony M. Hooper, Samuel Dufour, Xaoli He, Alexander Muck, Jing-Jiang Zhou, Reinaldo Almeida, Linda M. Field, Ale
Svato and John A. Pickett,
Chem. Commun., 2009, 5725
DOI: 10.1039/b914294k
Cell separation by an aqueous two-phase system in a microfluidic device
Masatoshi Tsukamoto, Shu Taira, Shohei Yamamura, Yasutaka Morita, Naoki Nagatani, Yuzuru Takamura and Eiichi Tamiya,
Analyst, 2009, 134, 1994
DOI: 10.1039/b909597g
An ultrasensitive DNAzyme-based colorimetric strategy for nucleic acid detection
Rongzhan Fu, Taihua Li and Hyun Gyu Park,
Chem. Commun., 2009, 5838
DOI: 10.1039/b907762f Enhanced HTML article available
Chemical regeneration of human tooth enamel under near-physiological conditions
Yujing Yin, Song Yun, Jieshi Fang and Haifeng Chen,
Chem. Commun., 2009, 5892
DOI: 10.1039/b911407f Enhanced HTML article available
Papers
The enzymatic nature of fungal bioluminescence
Anderson G. Oliveira and Cassius V. Stevani,
Photochem. Photobiol. Sci., 2009, 8, 1416
DOI: 10.1039/b908982a
Silencing of ALA dehydratase affects ALA-photodynamic therapy efficacy in K562 erythroleukemic cells
Tamar Feuerstein, Avital Schauder and Zvi Malik,
Photochem. Photobiol. Sci., 2009, 8, 1461
DOI: 10.1039/b9pp00007k
Secondary oxidants in human serum exposed to singlet oxygen: the influence of hemolysis
David Olivier, Samuel Douillard, Isabelle Lhommeau, Edith Bigot and Thierry Patrice,
Photochem. Photobiol. Sci., 2009, 8, 1476
DOI: 10.1039/b9pp00032a
Nucleoside triphosphate mimicry: a sugar triazolyl nucleoside as an ATP-competitive inhibitor of B. anthracis pantothenate kinase
Andrew S. Rowan, Nathan I. Nicely, Nicola Cochrane, Wjatschesslaw A. Wlassoff, Al Claiborne and Chris J. Hamilton,
Org. Biomol. Chem., 2009, 7, 4029
DOI: 10.1039/b909729e
A colorimetric and fluorescent merocyanine-based probe for biological thiols
Shu-Ping Wang, Wu-Jian Deng, Dan Sun, Min Yan, Hong Zheng and Jin-Gou Xu,
Org. Biomol. Chem., 2009, 7, 4017
DOI: 10.1039/b909760k
Photothermal sensitisation and therapeutic properties of a novel far-red absorbing cyanine
Monica Camerin, Giulio Jori, Leopoldo Della Ciana, Serena Fabbroni, Sara Bonacchi, Marco Montalti and Luca Prodi,
Photochem. Photobiol. Sci., 2009, 8, 1422
DOI: 10.1039/b908495a
FtmOx1, a non-heme Fe(II) and 
-ketoglutarate-dependent dioxygenase, catalyses the endoperoxide formation of verruculogen in Aspergillus fumigatus
Nicola Steffan, Alexander Grundmann, Shamil Afiyatullov, Hanli Ruan and Shu-Ming Li,
Org. Biomol. Chem., 2009, 7, 4082
DOI: 10.1039/b908392h
Modes of inactivation of trichodiene synthase by a cyclopropane-containing farnesyldiphosphate analog
Young J. Hong and Dean J. Tantillo,
Org. Biomol. Chem., 2009, 7, 4101
DOI: 10.1039/b908738a
A gorge-spanning, high-affinity cholinesterase inhibitor to explore -amyloid plaques
Paul W. Elsinghorst, Wolfgang Härtig, Simone Goldhammer, Jens Grosche and Michael Gütschow,
Org. Biomol. Chem., 2009, 7, 3940
DOI: 10.1039/b909612d
Synthesis of chiloglottones – semiochemicals from sexually deceptive orchids and their pollinators
Jacqueline Poldy, Rod Peakall and Russell Allan Barrow,
Org. Biomol. Chem., 2009, 7, 4296
DOI: 10.1039/b912233h
ITAM-derived phosphopeptide-containing dendrimers as multivalent ligands for Syk tandem SH2 domain
Joeri Kuil, Hilbert M. Branderhorst, Roland J. Pieters, Nico J. de Mol and Rob M. J. Liskamp,
Org. Biomol. Chem., 2009, 7, 4088
DOI: 10.1039/b905938e
A new assay format for NF-
B based on a DNA triple helix and a fluorescence resonance energy transfer
Dominik Altevogt, Andrea Hrenn, Claudia Kern, Lilia Clima, Willi Bannwarth and Irmgard Merfort,
Org. Biomol. Chem., 2009, 7, 3934
DOI: 10.1039/b906447h
Selectivity of small molecule ligands for parallel and anti-parallel DNA G-quadruplex structures
Thomas P. Garner, Huw E. L. Williams, Katarzyna I. Gluszyk, Stephen Roe, Neil J. Oldham, Malcolm F. G. Stevens, John E. Moses and Mark S. Searle,
Org. Biomol. Chem., 2009, 7, 4194
DOI: 10.1039/b910505k
Biotinylated disulfide containing PEI/avidin bioconjugate shows specific enhanced transfection efficiency in HepG2 cells
Xuan Zeng, Yun-Xia Sun, Xian-Zheng Zhang and Ren-Xi Zhuo,
Org. Biomol. Chem., 2009, 7, 4201
DOI: 10.1039/b910831a
Novel 7-(dimethylamino)fluorene-based fluorescent probes and their binding to human serum albumin
Kwanghee Koh Park, Joon Woo Park and Andrew D. Hamilton,
Org. Biomol. Chem., 2009, 7, 4225
DOI: 10.1039/b911605b
Biochemical characterization and substrate specificity of the gene cluster for biosyntheses of K-252a and its analogs by in vitro heterologous expression system of Escherichia coli
Hsien-Tai Chiu, Yu-Chin Lin, Meng-Na Lee, Yi-Lin Chen, Mei-Sin Wang and Chia-Chun Lai,
Mol. BioSyst., 2009, 5, 1192
DOI: 10.1039/b912395b Enhanced HTML article available
Synthesis of neamine-derived pseudodisaccharides by stereo- and regio-selective functional group transformations
Li-Juan Pang, Dan Wang, Jian Zhou, Li-He Zhang and Xin-Shan Ye,
Org. Biomol. Chem., 2009, 7, 4252
DOI: 10.1039/b907518f
Simultaneous and site-directed incorporation of an ester linkage and an azide group into a polypeptide by in vitro translation
Martin Humenik, Yiwei Huang, Igor Safronov and Mathias Sprinzl,
Org. Biomol. Chem., 2009, 7, 4218
DOI: 10.1039/b909188b
Carbon nanotubes as a protein toxin transporter for selective HER2-positive breast cancer cell destruction
Xuexiang Weng, Meiyan Wang, Jing Ge, Shaoning Yu, Baohong Liu, Jiang Zhong and Jilie Kong,
Mol. BioSyst., 2009, 5, 1224
DOI: 10.1039/b906948h Enhanced HTML article available
Network-level analysis of light adaptation in rod cells under normal and altered conditions
Daniele Dell
Orco, Henning Schmidt, Simona Mariani and Francesca Fanelli,
Mol. BioSyst., 2009, 5, 1232
DOI: 10.1039/b908123b Enhanced HTML article available
Zinc-activated C-peptide resistance to the type 2 diabetic erythrocyte is associated with hyperglycemia-induced phosphatidylserine externalization and reversed by metformin
Jennifer A. Meyer, Wasanthi Subasinghe, Anders A. F. Sima, Zachary Keltner, Gavin E. Reid, David Daleke and Dana M. Spence,
Mol. BioSyst., 2009, 5, 1157
DOI: 10.1039/b908241g Enhanced HTML article available
Antibacterial activity and cytotoxicity of PEGylated poly(amidoamine) dendrimers
Analette I. Lopez, Rose Y. Reins, Alison M. McDermott, Barbara W. Trautner and Chengzhi Cai,
Mol. BioSyst., 2009, 5, 1148
DOI: 10.1039/b904746h Enhanced HTML article available
Enhanced levels of mitochondrial enzyme 17-hydroxysteroid dehydrogenase type 10 in patients with Alzheimer disease and multiple sclerosis
Zdena Kritofiková, Markéta Bocková, Kate
ina Hegnerová, Ale Barto, Jan Klaschka, Jan 
í
ný, Daniela ípová and Jií Homola,
Mol. BioSyst., 2009, 5, 1174
DOI: 10.1039/b904799a Enhanced HTML article available
Molecular cloning, sequence analysis and functional characterization of the gene cluster for biosynthesis of K-252a and its analogs
Hsien-Tai Chiu, Yi-Lin Chen, Chien-Yu Chen, Chyn Jin, Meng-Na Lee and Yu-Chin Lin,
Mol. BioSyst., 2009, 5, 1180
DOI: 10.1039/b905293c Enhanced HTML article available
