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Feature Article

Chem. Commun., 2007, 4197 - 4208, DOI: 10.1039/b704873d

CO and NO in medicine

Brian E. Mann and Roberto Motterlini

The occurrence, role and consequences of CO and NO in biological systems are reviewed. This includes their syntheses by heme oxygenases and NO synthases, their biological targets and the physiological effects of their signals. The use of CO and NO gases in medicine are discussed and methods of delivery are illustrated with particular emphasis on the therapeutic properties of compounds that generate controlled amounts of NO and CO in vivo.

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