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Chem. Commun., 2009, 5377 - 5379, DOI: 10.1039/b910677d

Computational design, synthesis, and evaluation of miniproteins as androgen receptor coactivator mimics

Belen Vaz, Sabine Möcklinghoff, Simon Folkertsma, Scott Lusher, Jacob de Vlieg and Luc Brunsveld

Insertion of 3 to 4 mutations, based on in silico modelling, in a diverse set of natural miniproteins generates potent androgen receptor (AR) binders and a clear insight into the structure–activity relationship of such coactivator mimics concerning helix length.

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