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Chem. Commun., 2009, 5612 - 5614, DOI: 10.1039/b913019e

Barriers to enantiocontrol in Lewis acid catalyzed hetero-Diels–Alder reactions

Xiaochen Wang, Zhuoyan Li and Michael P. Doyle

Lewis bases, including reactant aldehydes, inhibit the rate of conversion for cycloaddition and those, like aldehydes or nitriles, cause a decrease in enantiocontrol due to the Lewis acidity of the activated complex.

Graphical abstract image for this article (ID: b913019e)