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Chem. Commun., 2009, 5722 - 5724, DOI: 10.1039/b914271c

Asymmetric meso-aziridine ring-opening reactions using a chiral zirconium catalyst

Kazutaka Seki, Rongmin Yu, Yumi Yamazaki, Yasuhiro Yamashita and Sh Kobayashi

A chiral zirconium catalyst prepared from Zr(OtBu)4 and a chiral tridentate BINOL was found to be effective for asymmetric meso-aziridine ring-opening reactions with aniline derivatives. The N-benzhydryl group on the product obtained was easily cleaved to give the corresponding amine in high yield under reductive conditions.

Graphical abstract image for this article (ID: b914271c)