_tcm18-11397.gif )
Urgent high quality communications from across the chemical sciences.
Subscribers
Non-subscribers
- Purchase article PDF [£27 + taxes]
- Purchase article PDF member offer [£5 + taxes]
Free access
Communication
Chem. Commun., 2009, 6756 - 6758, DOI: 10.1039/b917312a
Optimized DNA-targeting using triplex forming C5-alkynyl functionalized LNA
Sujay P. Sau, Pawan Kumar, Brooke A. Anderson, Michael E. Østergaard, Lee Deobald, Andrzej Paszczynski, Pawan K. Sharma and Patrick J. Hrdlicka
Triplex forming oligonucleotides (TFOs) modified with C5-alkynyl functionalized LNA (locked nucleic acid) monomers display extraordinary thermal affinity toward double stranded DNA targets, excellent discrimination of Hoogsteen-mismatched targets, and high stability against 3
-exonucleases.
RSS feed