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Dalton Transactions

The international journal for inorganic, organometallic and bioinorganic chemistry



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Dalton Trans., 2007, 1140 - 1149, DOI: 10.1039/b614878f

Chemical speciation of copper(II) diaminediamide derivative of pentacycloundecane—a potential anti-inflammatory agent

Sebusi Odisitse, Graham E. Jackson, Thavendran Govender, Hendrik G. Kruger and Amith Singh

Formation constants of copper(II), zinc(II) and calcium(II) with 3,5-diaminodiamido-4-oxahexacyclododecane (cageL) has been studied by glass electrode potentiometry at 25 °C and an ionic strength of 0.15 mol dm–3. Copper(II) forms more stable complexes with cageL than zinc(II) and calcium(II). Metal ion complexation promotes deprotonation and coordination of the amide nitrogens resulting in overall tetragonal coordination of Cu2+ suggested by the UV-visible electronic spectra. Speciation calculations using a blood plasma model suggest that zinc(II) and calcium(II) are good competitors of copper(II) in vivo. Bio-distribution experiments using 64Cu-labelled Cu(II)-cageL show that about 50% dose of the complex is retained in the body after 24 h.

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