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Dalton Transactions

The international journal for inorganic, organometallic and bioinorganic chemistry



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Dalton Trans., 2009, 9812 - 9819, DOI: 10.1039/b915839a

A glycine ruthenium trithiacyclononane complex and its molecular encapsulation using cyclodextrins

Joana Marques, Teresa M. Santos, Maria Paula Marques and Susana S. Braga

The complex Ru([9]aneS3)(gly)Cl (gly = glycine) was obtained from the reaction of the precursor Ru([9]aneS3)dmsoCl2 with glycine and encapsulated into native -CD, a hydroxypropylated derivative HPCD, and the methylated cyclodextrins TRIMEB and CRYSMEB. All four inclusion compounds were obtained with a 1:1 host:guest stoichiometry and characterised in the solid-state by powder X-ray diffraction, thermogravimetric analysis (TGA), and 13C{1H} CP/MAS NMR and FTIR spectroscopies. The cytostatic and antiproliferative activity of the complex Ru([9]aneS3)(gly)Cl and its four CD inclusion compounds was tested on the human osteosarcoma MG-63 cell line and the results compared to the inhibitory effect exerted by the pure cyclodextrins.

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