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Paper

Green Chem., 2009, 11, 1906 - 1914, DOI: 10.1039/b916765j

Water as the medium of choice for the 1,3-dipolar cycloaddition reactions of hydrophobic nitrones

Evdoxia Coutouli-Argyropoulou, Prodromos Sarridis and Petros Gkizis

1,3-Dipolar cycloadditions of different hydrophobic nitrones 1, 2, 3, 4 with acrylates 5 and 6 were studied in both homogenous organic solutions and aqueous suspensions. Reactions in water suspensions showed great rate accelerations over homogenous solutions. Small changes were also observed to the stereoselectivities of the reactions. Hydrophobic interactions are invoked for the observed behaviour.

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