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Lab on a Chip

Microfluidic & nanofluidic technologies for chemistry, physics, biology, and bioengineering



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Critical Review

Lab Chip, 2009, 9, 2524 - 2536, DOI: 10.1039/b900683b


On-chip technologies for multidimensional separations

Samuel Tia and Amy E. Herr


We review microfluidic devices designed for multidimensional sample analysis, with a primer on relevant theory, an emphasis on protein analysis, and an eye towards future improvements and challenges to the field. Image shows results of an on-chip IEF-CE separation of a protein mixture; unpublished surface plot data from A. E. Herr.

Graphical abstract image for this article  (ID: b900683b)