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Molecular BioSystems

Research at the interface between chemistry and the -omic sciences and systems biology.



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Mol. BioSyst., 2007, 3, 773 - 780, DOI: 10.1039/b701169e

Targeting neurological disease with RNAi

Paul Lingor and Mathias Bähr

The neuroscientific community rapidly adopted RNA interference techniques as an experimental tool for the dissection of gene function in vitro and in animal models of neurological disease in vivo. Here, we discuss recent advances in the biotechnical implementation of siRNA/shRNA-mediated gene silencing focusing on issues of design, delivery and putative detrimental effects. We then summarize the current use of RNAi in targeting neurological disease models and give an outlook on the implementation of this technique in clinical therapy.

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