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Research at the interface between chemistry and the -omic sciences and systems biology.
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Mol. BioSyst., 2008, 4, 300 - 308, DOI: 10.1039/b718447f
Gene regulation technologies in zebrafish
Hanife Esengil and James K. Chen
Achieving the potential of zebrafish models in biomedical research is contingent on the development of reverse-genetic resources. This review describes current technologies for genetic perturbations in zebrafish, including an ecdysone receptor-based system that permits conditional transgene expression. Such methodologies promise to enable new zebrafish models for interrogating human physiology and disease.
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