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Interview: Sweet Science
05 November 2009
David Jakeman talks about carbohydrates, drugs and meeting Darwin. Interview by Nicola Wise
2010 NPR Lecture Award nominations open
05 November 2009
Nominations for the 2010 NPR Lecture Award are now open
Directing Biosynthesis 2010: Discovery, Evolution, Function
Further information on this conference to be held from 15 - 17 September 2010 in Durham, UK.
NPR news archive
Contents list for Natural Product Reports, issue 11, 2009
Front cover
Nat. Prod. Rep., 2009, 26, 1353
DOI: 10.1039/b921007p
Contents and Highlights in Chemical Biology
Nat. Prod. Rep., 2009, 26, 1355
DOI: 10.1039/b921008n
Editorial
Editorial: Genomics themed issue
Nat. Prod. Rep., 2009, 26, 1361
DOI: 10.1039/b918715b
Reviews
Genomic basis for natural product biosynthetic diversity in the actinomycetes
Markus Nett, Haruo Ikeda and Bradley S. Moore,
Nat. Prod. Rep., 2009, 26, 1362
DOI: 10.1039/b817069j
By presenting the recently sequenced actinobacterial genomes, we highlight the unsurpassed potential of this bacterial lineage for natural product biosynthesis and discuss metabolic trends that have emerged from comparative genomics.
The impact of genomics on the exploitation of the myxobacterial secondary metabolome
Silke C. Wenzel and Rolf Müller,
Nat. Prod. Rep., 2009, 26, 1385
DOI: 10.1039/b817073h
Myxobacteria are one of the most outstanding resources for microbial natural products. This review focuses on the impact of genomics on the evaluation and exploitation of their biosynthetic potential (2000–2009).
Genomics of secondary metabolite production by Pseudomonas spp.
Harald Gross and Joyce E. Loper,
Nat. Prod. Rep., 2009, 26, 1408
DOI: 10.1039/b817075b
Pseudomonas spp. produce a large spectrum of structurally-diverse, bioactive natural products, and genomics has further highlighted the enormous metabolic capacity of the genus. This review provides an overview of secondary metabolite biosynthesis in Pseudomonas spp., and the central role of genomics in natural product discovery, characterization of metabolic gene clusters and patterns of their inheritance.
Mining cyanobacterial genomes for genes encoding complex biosynthetic pathways
John A. Kalaitzis, Federico M. Lauro and Brett A. Neilan,
Nat. Prod. Rep., 2009, 26, 1447
DOI: 10.1039/b817074f
This review describes genome mining of cyanobacteria for natural product discovery and biosynthesis pathways. Also presented is an overview of the genetic basis of natural product biosynthesis in cyanobacteria.
Functional genomics for plant natural product biosynthesis
Keiko Yonekura-Sakakibara and Kazuki Saito,
Nat. Prod. Rep., 2009, 26, 1466
DOI: 10.1039/b817077k
This review covers the recent study of plant secondary metabolism, including the metabolic pathways that produce flavonoids, alkaloids and terpenoids, facilitated by the development of functional plant genomics.
Metagenomic approaches to natural products from free-living and symbiotic organisms
Sean F. Brady, Luke Simmons, Jeffrey H. Kim and Eric W. Schmidt,
Nat. Prod. Rep., 2009, 26, 1488
DOI: 10.1039/b817078a
Uncultivated bacteria from diverse environments, including soils and the interior of animals, are new sources for natural products discovery. Methods and milestones in accessing this environmental DNA and the resulting natural products are described.
Back matter
Nat. Prod. Rep., 2009, 26, 1504
DOI: 10.1039/b921012c
Back cover
Nat. Prod. Rep., 2009, 26, 1507
DOI: 10.1039/b921009c
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