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Nat. Prod. Rep., 2009, 26, 155 - 169, DOI: 10.1039/b817092b

Heterologous expression systems for polyketide synthases

Isao Fujii

Polyketide synthases are the main biochemical machinery for the production of a structurally diverse group of natural products, polyketides. Their heterologous expression enables overproduction of target compounds, generation of novel analogs, and provides a basic understanding of their reaction programs. This Highlight outlines the current state of heterologous expression of type I, type II, and type III polyketide synthases of microbial and plant origins.

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