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Latest News
Issue 5 of NPR now online
30 September 2008
The latest issue of Natural Product Reports is now available online
Cells take direction from virus
18 September 2008
Liquid crystalline scaffold imparts order on cell arrangement
NPR Board Member given RSC award
04 August 2008
Emma Raven (University of Leicester), a member of the Editorial Board for NPR has won the RSC 2008 award for Reaction Kinetics and Mechanisms.
NPR news archive
Contents list for Natural Product Reports, issue 5, 2008
Front cover
Nat. Prod. Rep., 2008, 25, 833
DOI: 10.1039/b815870n
Contents and Chemical Biology
Nat. Prod. Rep., 2008, 25, 835
DOI: 10.1039/b815871c
Hot off the Press Article
Hot off the press
Robert A. Hill and Andrew Sutherland,
Nat. Prod. Rep., 2008, 25, 841
DOI: 10.1039/b814878n
A personal selection of 29 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as cladoniamide A from Streptomyces uncialis.
Highlights
Isoprenoid-like alkylations in polyketide biosynthesis
Christopher T. Calderone,
Nat. Prod. Rep., 2008, 25, 845
DOI: 10.1039/b807243d
This Highlight details a recently characterized isoprenoid-like 
-alkylation pathway utilized in polyketide biosynthesis, with particular emphasis on its parallels with canonical isoprenoid biosynthesis and the structures that can be accessed by this strategy.
Tedanolide and the evolution of polyketide inhibitors of eukaryotic protein synthesis
Richard E. Taylor,
Nat. Prod. Rep., 2008, 25, 854
DOI: 10.1039/b805700c
This Highlight covers the chemical and biological studies regarding a set of polyketide inhibitors of eukaryotic protein synthesis related to the marine-derived cytotoxic agent tedanolide.
Syntheses of the tedanolides
Myriam Roy and Markus Kalesse,
Nat. Prod. Rep., 2008, 25, 862
DOI: 10.1039/b719607e
Twenty-four years after its first publication tedanolide was synthesized for the first time. A large body of synthetic contributions has provided novel strategies and methods that culminated in the syntheses of tedanolide and 13-deoxytedanolide.
Review Articles
Triterpenoids from the Schisandraceae family
Wei-Lie Xiao, Rong-Tao Li, Sheng-Xiong Huang, Jian-Xin Pu and Han-Dong Sun,
Nat. Prod. Rep., 2008, 25, 871
DOI: 10.1039/b719905h
This review covers the structures, proposed biosynthetic pathways, total synthesis and biological activities of triterpenoids (especially highly oxygenated nortriterpenoids) from the plants of the family Schisandraceae from 1973 until January 2008.
Scaffold diversity of natural products: inspiration for combinatorial library design
Kristina Grabowski, Karl-Heinz Baringhaus and Gisbert Schneider,
Nat. Prod. Rep., 2008, 25, 892
DOI: 10.1039/b715668p
Although natural products and drugs have remarkably different properties in general, they show similarity in their pharmacophores. Computer-assisted scaffold extraction from natural products provides new chemotypes and prospects for drug discovery.
New methods for stereochemical determination of complex polyketides: configurational assignment of novel metabolites from myxobacteria
Dirk Menche,
Nat. Prod. Rep., 2008, 25, 905
DOI: 10.1039/b707989n
An overview on recently developed methods for the stereochemical determination of complex polyketides is given and NMR-spectroscopic, computational, biosynthetic and synthetic methods are discussed. These methods are presented in their applications to structurally novel polyketide classes from myxobacteria.
The chemistry and biology of organic guanidine derivatives
Roberto G. S. Berlinck, Antonio Carlos B. Burtoloso and Miriam H. Kossuga,
Nat. Prod. Rep., 2008, 25, 919
DOI: 10.1039/b507874c
Organic guanidine compounds are reviewed, with emphasis on natural product isolation, identification, synthesis and biological activities. The literature survey includes purely synthetic guanidine derivatives, guanidine alkaloids and non-ribosomal peptides from bacteria and cyanobacteria, as well as related compounds isolated from marine and terrestrial invertebrates and higher plants.
Natural products from true mangrove flora: source, chemistry and bioactivities
Jun Wu, Qiang Xiao, Jing Xu, Min-Yi Li, Jian-Yu Pan and Mei-hua Yang,
Nat. Prod. Rep., 2008, 25, 955
DOI: 10.1039/b807365a
This review summarizes the source, chemistry and bioactivities of natural products from true mangrove species worldwide with literature coverage from 1913 to February 2008. It includes 349 metabolites and 150 references. The molecular phylogeny and chemotaxonomy of true mangrove plants are discussed.
Back matter
Nat. Prod. Rep., 2008, 25, 982
DOI: 10.1039/b815872j
Back cover
Nat. Prod. Rep., 2008, 25, 987
DOI: 10.1039/b815873h
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