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Nanoscale

A new peer reviewed journal publishing experimental and theoretical work across the breadth of nanoscience and nanotechnology



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Paper

Nanoscale, 2009, 1, 159 - 163, DOI: 10.1039/b9nr00092e

Ultra-sensitive detection of adipocytokines with CMOS-compatible silicon nanowire arrays

Tze-Sian Pui, Ajay Agarwal, Feng Ye, Zhi-Qiang Tou, Yinxi Huang and Peng Chen

Perfectly aligned arrays of single-crystalline silicon nanowires were fabricated using top-down CMOS-compatible techniques. We demonstrate that these nanowire devices are able to detect adipocytokines secreted by adipose cells with femtomolar sensitivity, high specificity, wide detection range, and ability for parallel monitoring. The nanowire sensors also provide a novel tool to reveal the poorly understood signaling mechanisms of these newly recognized signaling molecules, as well as their relevance in common diseases such as obesity and diabetes.

Graphical abstract image for this article (ID: b9nr00092e)