The outside front cover, designed by Patrick Guiry, at University College Dublin, Ireland, and colleagues depicts Irish chirality old and new: the spiral background is taken from a 5000 year old Irish design found at the entrance to a Neolithic passage tomb at Newgrange, Ireland. The entrance to the tomb is shown in the inset image. The cover represents their work on the synthesis and resolution of a new axially chiral quinazolinap ligand.

The inside front cover, supplied by Perspective author Olivia Reinaud, at Paris Descartes University, France, and colleagues, shows calix[6]arenes shaped into conic funnels through biomimetic coordination chemistry or self-assembly. They are remarkable receptors for neutral guests and their versatility allows tuning and switching behaviours.