The outside front cover was provided by Harald Kolmar, at Darmstadt University of Technology, Germany, and colleagues. It illustrates their work on the generation of tetravalent peptide conjugates via a copper(I) catalysed azide-alkyne cycloaddition using a cyclic peptide template as a versatile conjugation scaffold. 

The inside front cover is a picture of Yunnan Garden, which sits in front of the Division of Chemistry and Biological Chemistry at Nanyang Technological University, Singapore, where OBC author Philip Wai Hong Chan's group is based. Chan and colleagues have developed a general and efficient iron-catalysed method for the direct nucleophilic -substitution of Morita-Baylis-Hillman alcohols with a structurally diverse set of nucleophiles, including alcohols, arenes, 1,3-dicarbonyl compounds and thiols. 

This issue's Perspective by Gregory Dudley and Douglas Engel, at Florida State University, Tallahassee, US, describes recent advances in the Meyer-Schuster rearrangement, which enables the atom economical olefination of ketones and aldehydes, including those beyond the scope of other olefination methods.