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Organic & Biomolecular Chemistry

The international home of synthetic, physical and biomolecular organic chemistry.



Read OBC's Perspectives



Perspective Articles are either a concise and critical appraisal or a personal viewpoint of activity in a specialist area of organic chemistry. Perspective articles will be easy-to-read articles covering current areas of interest and not comprehensive reviews of the literature. These are normally published by invitation of the OBC Editorial Board. However, suggestions from authors are welcome and enquiries regarding the submission of Perspective Articles should be directed to the editor.

The tert-butyl group in chemistry and biology
Philippe Bisel, Loay Al-Momani and Michael Müller, Org. Biomol. Chem., 2008, 6, 2655
DOI: 10.1039/b800083b
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Bright molecules with sense, logic, numeracy and utility
A. Prasanna de Silva, Thomas P. Vance, Matthew E. S. West and Glenn D. Wright, Org. Biomol. Chem., 2008, 6, 2468
DOI: 10.1039/b802963f
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Cell-penetrating peptides as delivery vehicles for biology and medicine
Kelly M. Stewart, Kristin L. Horton and Shana O. Kelley, Org. Biomol. Chem., 2008, 6, 2242
DOI: 10.1039/b719950c
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Modulating the electronic properties of porphyrinoids: a voyage from the violet to the infrared regions of the electromagnetic spectrum
Yannick Rio, M. Salomé Rodríguez-Morgade and Tomás Torres, Org. Biomol. Chem., 2008, 6, 1877
DOI: 10.1039/b800617b
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Catalytic addition of alkyne C–H, amine N–H, and phosphine P–H bonds to carbodiimides: an efficient route to propiolamidines, guanidines, and phosphaguanidines
Wen-Xiong Zhang and Zhaomin Hou, Org. Biomol. Chem., 2008, 6, 1720
DOI: 10.1039/b800135a
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Nucleoside, nucleotide and oligonucleotide based amphiphiles: a successful marriage of nucleic acids with lipids
Arnaud Gissot, Michel Camplo, Mark W. Grinstaff and Philippe Barthélémy, Org. Biomol. Chem., 2008, 6, 1324
DOI: 10.1039/b719280k
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Diversity-oriented synthesis; a spectrum of approaches and results
Richard J. Spandl, Andreas Bender and David R. Spring, Org. Biomol. Chem., 2008, 6, 1149
DOI: 10.1039/b719372f
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Structure-and-mechanism-based design and discovery of therapeutics for cocaine overdose and addiction
Fang Zheng and Chang-Guo Zhan, Org. Biomol. Chem., 2008, 6, 836
DOI: 10.1039/b716268e
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Thiol cofactors for selenoenzymes and their synthetic mimics
Bani Kanta Sarma and Govindasamy Mugesh, Org. Biomol. Chem., 2008, 6, 965
DOI: 10.1039/b716239a
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Natural and synthetic quinones and their reduction by the quinone reductase enzyme NQO1: from synthetic organic chemistry to compounds with anticancer potential
Marie A. Colucci, Gavin D. Couch and Christopher J. Moody, Org. Biomol. Chem., 2008, 6, 637
DOI: 10.1039/b715270a
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Unlocking the potential of bile acids in synthesis, supramolecular/materials chemistry and nanoscience
Nonappa and Uday Maitra, Org. Biomol. Chem., 2008, 6, 657
DOI: 10.1039/b714475j
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Natural products: chemical instruments to apprehend biological symphony
Mathieu Pucheault, Org. Biomol. Chem., 2008, 6, 424
DOI: 10.1039/b713022h
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The [1,3] O-to-C rearrangement: opportunities for stereoselective synthesis
Christopher G. Nasveschuk and Tomislav Rovis, Org. Biomol. Chem., 2008, 6, 240
DOI: 10.1039/b714881j
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Designer aminoglycosides: the race to develop improved antibiotics and compounds for the treatment of human genetic diseases
Mariana Hainrichson, Igor Nudelman and Timor Baasov, Org. Biomol. Chem., 2008, 6, 227
DOI: 10.1039/b712690p
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Chiral recognition in noncovalent bonding interactions between helicenes: right-handed helix favors right-handed helix over left-handed helix
Ryo Amemiya and Masahiko Yamaguchi, Org. Biomol. Chem., 2008, 6, 26
DOI: 10.1039/b713700a
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Molecular rearrangements through thermal [1,3] carbon shifts
John E. Baldwin and Phyllis A. Leber, Org. Biomol. Chem., 2008, 6, 36
DOI: 10.1039/b711494j
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2007

Current molecular design of intelligent drugs and imaging probes targeting tumor-specific microenvironments
Kazuhito Tanabe, Zhouen Zhang, Takeo Ito, Hiroshi Hatta and Sei-ichi Nishimoto, Org. Biomol. Chem., 2007, 5, 3745
DOI: 10.1039/b711244k

Design and synthesis of -helical peptides and mimetics
James Garner and Margaret M. Harding, Org. Biomol. Chem., 2007, 5, 3577
DOI: 10.1039/b710425a

Advances in the metallotropic [1,3]-shift of alkynyl carbenoids
Daesung Lee and Mansuk Kim, Org. Biomol. Chem., 2007, 5, 3418
DOI: 10.1039/b710379d

Asymmetric organocatalytic reductions mediated by dihydropyridines
Stephen J. Connon, Org. Biomol. Chem., 2007, 5, 3407
DOI: 10.1039/b711499k

Recent highlights in modified oligonucleotide chemistry
Alexander J. A. Cobb, Org. Biomol. Chem., 2007, 5, 3260
DOI: 10.1039/b709797m

Total synthesis approaches to natural product derivatives based on the combination of chemical synthesis and metabolic engineering
Andreas Kirschning, Florian Taft and Tobias Knobloch, Org. Biomol. Chem., 2007, 5, 3245
DOI: 10.1039/b709549j

Synthesis of azabicyclic systems using nitrogen-directed radical rearrangements
David M. Hodgson and Leonard H. Winning, Org. Biomol. Chem., 2007, 5, 3071
DOI: 10.1039/b707566a

Intramolecular cation– interaction in organic synthesis
Shinji Yamada, Org. Biomol. Chem., 2007, 5, 2903
DOI: 10.1039/b706512b

Utilisation of plant viruses in bionanotechnology
Nicole F. Steinmetz and David J. Evans, Org. Biomol. Chem., 2007, 5, 2891
DOI: 10.1039/b708175h

Photochemical transformations of pyridinium salts: mechanistic studies and applications in synthesis
Teresa Damiano, Daniel Morton and Adam Nelson, Org. Biomol. Chem., 2007, 5, 2735
DOI: 10.1039/b706244n

Fast electron density methods in the life sciences—a routine application in the future?
Peter Luger, Org. Biomol. Chem., 2007, 5, 2529
DOI: 10.1039/b706235d

Nicotinamide adenine dinucleotide: beyond a redox coenzyme
Hening Lin, Org. Biomol. Chem., 2007, 5, 2541
DOI: 10.1039/b706887e

Functional molecules in electronic circuits
Nicolas Weibel, Sergio Grunder and Marcel Mayor, Org. Biomol. Chem., 2007, 5, 2343
DOI: 10.1039/b703287k

Oligosaccharide assembly by one-pot multi-step strategy
Yuhang Wang, Xin-Shan Ye and Li-He Zhang, Org. Biomol. Chem., 2007, 5, 2189
DOI: 10.1039/b704586g

Catalytic enantioselective construction of tetrasubstituted carbons by self-assembled poly rare earth metal complexes
Masakatsu Shibasaki and Motomu Kanai, Org. Biomol. Chem., 2007, 5, 2027
DOI: 10.1039/b704542e

Polyketides, proteins and genes in fungi: programmed nano-machines begin to reveal their secrets
Russell J. Cox, Org. Biomol. Chem., 2007, 5, 2010
DOI: 10.1039/b704420h

Designed evolution of artificial metalloenzymes: protein catalysts made to order
Marc Creus and Thomas R. Ward, Org. Biomol. Chem., 2007, 5, 1835
DOI: 10.1039/b702068f

Artificial photosynthetic systems: assemblies of slipped cofacial porphyrins and phthalocyanines showing strong electronic coupling
Akiharu Satake and Yoshiaki Kobuke, Org. Biomol. Chem., 2007, 5, 1679
DOI: 10.1039/b703405a

Polysulfides as biologically active ingredients of garlic
Ute Münchberg, Awais Anwar, Susanne Mecklenburg and Claus Jacob, Org. Biomol. Chem., 2007, 5, 1505
DOI: 10.1039/b703832a

What's new in stable radical chemistry?
Robin G. Hicks, Org. Biomol. Chem., 2007, 5, 1321
DOI: 10.1039/b617142g

Recent applications of the CuI-catalysed Huisgen azide–alkyne 1,3-dipolar cycloaddition reaction in carbohydrate chemistry
Simone Dedola, Sergey A. Nepogodiev and Robert A. Field, Org. Biomol. Chem., 2007, 5, 1006
DOI: 10.1039/b618048p

Asymmetric catalysis for the construction of quaternary carbon centres: nucleophilic addition on ketones and ketimines
Olivier Riant and Jérôme Hannedouche, Org. Biomol. Chem., 2007, 5, 873
DOI: 10.1039/b617746h

Density functional theory with dispersion corrections for supramolecular structures, aggregates, and complexes of (bio)organic molecules
Stefan Grimme, Jens Antony, Tobias Schwabe and Christian Mück-Lichtenfeld, Org. Biomol. Chem., 2007, 5, 741
DOI: 10.1039/b615319b

Robust platform for de novo production of heterologous polyketides and nonribosomal peptides in Escherichia coli
Kenji Watanabe and Hideaki Oikawa, Org. Biomol. Chem., 2007, 5, 593
DOI: 10.1039/b615589h

Recent approaches towards the asymmetric synthesis of ,-disubstituted -amino acids
Henning Vogt and Stefan Bräse, Org. Biomol. Chem., 2007, 5, 406
DOI: 10.1039/b611091f

New routes to organofluorine compounds based on ketenes and the radical transfer of xanthates
Samir Z. Zard, Org. Biomol. Chem., 2007, 5, 205
DOI: 10.1039/b615592h

Elucidating DNA damage and repair processes by independently generating reactive and metastable intermediates
Marc M. Greenberg, Org. Biomol. Chem., 2007, 5, 18
DOI: 10.1039/b612729k

The Heck–Mizoroki cross-coupling reaction: a mechanistic perspective
Jonathan P. Knowles and Andrew Whiting, Org. Biomol. Chem., 2007, 5, 31
DOI: 10.1039/b611547k

OBC Perspective Archive 2006

Perspectives from 2006

OBC Perspective Archive 2005

Perspectives from 2005

OBC Perspective Archive 2004

Perspectives from 2004

OBC Perspective Archive 2003

Perspectives from 2003