Paper

Org. Biomol. Chem., 2007, 5, 2583 - 2586, DOI: 10.1039/b708264a

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Sequence specific interstrand photocrosslinking for effective SNP typing

Takehiro Ami, Katsuya Ito, Yoshinaga Yoshimura and Kenzo Fujimoto

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We describe a simple and inexpensive SNP typing method by using sequence specific interstrand photocrosslinking via p-carbamoylvinyl phenol nucleosides. Interstrand photocrosslinking showed a high degree of single nucleotide specificity as high as 10³-fold and more, and can be used in the diagnostic detection of DNA sequences.

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