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Org. Biomol. Chem., 2009, 7, 840 - 850, DOI: 10.1039/b819067b
Inhibitors of phosphoinositide-3-kinase: a structure-based approach to understanding potency and selectivity
Teather J. Sundstrom, Amy C. Anderson and Dennis L. Wright
Phosphoinositide-3-kinase is a pivotal protein involved in a wide variety of signaling cascades and there has been a great deal of interest in the development of potent and selective inhibitors of this enzyme. In this review, the potency and selectivity of the known inhibitors is presented along with key structural information that helps rationalize the observed trends.
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