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Paper

Org. Biomol. Chem., 2009, 7, 3230 - 3235, DOI: 10.1039/b902041a

Saponins as novel TNF- inhibitors: isolation of saponins and a nor-pseudoguaianolide from Parthenium hysterophorus

Bhahwal Ali Shah, Renu Chib, Pankaj Gupta, Vijay Kumar Sethi, Surrinder Koul, Samar Singh Andotra, Amit Nargotra, Sujata Sharma, Anjali Pandey, Sarang Bani, Basant Purnima and Subhash Chandra Taneja

Two novel saponins and a 13-nor-pseudoguaianolide designated as hysterolactone were isolated from Parthenium hysterophorus. The two saponins were found to be potent inhibitors of TNF-. Their mode of inhibition was studied through molecular modeling. The wet lab results were in concordance with the data obtained from docking experiments.

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