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Communication
Org. Biomol. Chem., 2009, 7, 3372 - 3378, DOI: 10.1039/b910397j
High-yielding synthesis of Nefopam analogues (functionalized benzoxazocines) by sequential one-pot cascade operations
Dhevalapally B. Ramachary, Vidadala V. Narayana, M. Shiva Prasad and Kinthada Ramakumar
An efficient amine-/ruthenium-catalyzed three-step process for the synthesis of Nefopam analogues was achieved through combinations of cascade enamine amination/iso-aromatization/allylation and diene or enyne metathesis as key steps starting from functionalized Hagemann's esters. In this communication, we discovered the application of ruthenium-catalysis on olefins containing free amines without in situ formation of salts.
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