_tcm18-11415.gif )
The international home of synthetic, physical and biomolecular organic chemistry.
Paper
Org. Biomol. Chem., 2009, 7, 4598 - 4603, DOI: 10.1039/b912400d
Sensing of peptide hormones with dynamic combinatorial libraries of metal–dye complexes: the advantage of time-resolved measurements
Friederike Zaubitzer, Thomas Riis-Johannessen and Kay Severin
A dynamic combinatorial library of metal–dye complexes was obtained by reacting aqueous solutions of the dyes Methyl Calcein Blue, Arsenazo I, and Xylenol Orange with CuCl2 and NiCl2. The mixture gave a characteristic UV-Vis response upon addition of the peptide hormones angiotensin I and angiotensin II. This allowed distinguishing pure samples of peptide hormones from mixtures. The discriminatory power of the sensor was enhanced when the several UV/Vis measurements were performed during the equilibration process of the library.
RSS feed