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Org. Biomol. Chem., 2009, 7, 4567 - 4581, DOI: 10.1039/b913066g
1,3-Dipolar cycloadditions: applications to the synthesis of antiviral agents
Carmen Nájera and José M. Sansano
In the present perspective the advances and real possibilities of 1,3-dipolar cycloadditions as key steps in the total synthesis of virus inhibitors are described. Azides, nitrones, and azomethine ylides are the most appropriate 1,3-dipoles for the synthesis of privileged structures with the highest biological responses against viruses.
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