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Paper

Org. Biomol. Chem., 2009, 7, 4641 - 4646, DOI: 10.1039/b914265g

Synthesis of functionalized H-pyrazolo[5,1-a]isoquinolines via sequential reactions of N-(2-alkynylbenzylidene)hydrazides

Zhiyuan Chen, Mingchao Su, Xingxin Yu and Jie Wu

Diversity-oriented synthesis of functionalized H-pyrazolo[5,1-a]isoquinolines via sequential reactions of N-(2-alkynylbenzylidene)hydrazide is described. Bromine-mediated electrophilic cyclization, Ag-catalyzed alkyne nucleophilic addition, and palladium-catalyzed cross-coupling reaction were involved in the transformation.

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