_tcm18-11415.gif )
The international home of synthetic, physical and biomolecular organic chemistry.
Subscribers
Non-subscribers
- Purchase article PDF [£27 + taxes]
- Purchase article PDF member offer [£5 + taxes]
Free access
Paper
Org. Biomol. Chem., 2009, 7, 4695 - 4707, DOI: 10.1039/b914981c
Synthesis, photolysis studies and in vitro photorelease of caged TRPV1 agonists and antagonists
Michael P. Van Ryssen, Nicolaos Avlonitis, Rashid Giniatullin, Craig McDougall, James L. Carr, Megan N. Stanton-Humphreys, Emma L. A. Borgström, C. Tom A. Brown, Dmitriy Fayuk, Alexander Surin, Minna Niittykoski, Leonard Khiroug and Stuart J. Conway
The synthesis of a range of caged TRPV1 agonists and antagonists is reported. The photolysis characteristics of these compounds, when irradiated with a 355 nm laser, have been studied and in all cases the desired compound was produced. Photolysis of a caged TRPV1 agonist in cultured trigeminal neurons produced responses that were consistent with the activation of TRPV1 receptors.
RSS feed