Communication

Org. Biomol. Chem., 2009, 7, 4582 - 4585, DOI: 10.1039/b916744g

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Efficient synthesis of the C₇-C₂₀ subunit of amphidinolides C and F

Subham Mahapatra and Rich G. Carter

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Synthesis of the C₇-C₂₀ subunit of amphidinolides C and F has been accomplished utilizing a Me₃Al-mediated ring opening of a vinyl iodide/allylic epoxide to establish the C_12,13anti stereochemistry, an organolithium coupling/olefination sequence to construct the C₉-C₁₁ diene moiety and a sulfone alkylation/hydroxylation strategy to join the C₇-C₁₄ and C₁₅-C₂₀ fragments.

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