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Organic & Biomolecular Chemistry

The international home of synthetic, physical and biomolecular organic chemistry.



Natural products research articles in Organic & Biomolecular Chemistry



Organic & Biomolecular Chemistry publishes many aspects of natural products research - both cutting-edge new work and insightful review articles. Read more about our latest articles below.

Synthetic tetra-acylated derivatives of lipid A from Porphyromonas gingivalis are antagonists of human TLR4
Yanghui Zhang, Jidnyasa Gaekwad, Margreet A. Wolfert and Geert-Jan Boons, Org. Biomol. Chem., 2008, 6, 3371
DOI: 10.1039/b809090d
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The neomycin biosynthetic gene cluster of Streptomyces fradiae NCIMB 8233: genetic and biochemical evidence for the roles of two glycosyltransferases and a deacetylase
Qingzhi Fan, Fanglu Huang, Peter F. Leadlay and Jonathan B. Spencer, Org. Biomol. Chem., 2008, 6, 3306
DOI: 10.1039/b808734b
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Engineered biosynthesis of hybrid macrolide polyketides containing D-angolosamine and D-mycaminose moieties
Ursula Schell, Stephen F. Haydock, Andrew L. Kaja, Isabelle Carletti, Rachel E. Lill, Eliot Read, Lesley S. Sheehan, Lindsey Low, Maria-Jose Fernandez, Friederike Grolle, Hamish A. I. McArthur, Rose M. Sheridan, Peter F. Leadlay, Barrie Wilkinson and Sabine Gaisser, Org. Biomol. Chem., 2008, 6, 3315
DOI: 10.1039/b807914e
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Total synthesis of cucurbitaxanthin A, cycloviolaxanthin and capsanthin 3,6-epoxide by applying a regioselective ring opening of tetrasubstituted epoxides
Yumiko Yamano, Masayoshi Ito and Akimori Wada, Org. Biomol. Chem., 2008, 6, 3421
DOI: 10.1039/b807482h
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A new synthetic approach to (+)-lactacystin based on radical cyclisation of enantiopure -ethynyl substituted serine derivatives to 4-methylenepyrrolidinones
Gerald Pattenden and Gwenaëlla Rescourio, Org. Biomol. Chem., 2008, 6, 3428
DOI: 10.1039/b806681g
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Synthesis and in vitro evaluation of imidazole-based wakayin analogues
Hung Hoang, Xiaofen Huang and Edward B. Skibo, Org. Biomol. Chem., 2008, 6, 3059
DOI: 10.1039/b806883f
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Stereocontrolled synthesis of lepadiformine A
Barry Lygo, Eirene H. M. Kirton and Christopher Lumley, Org. Biomol. Chem., 2008, 6, 3085
DOI: 10.1039/b805951a
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Exploring the substrate specificity of OxyB, a phenol coupling P450 enzyme involved in vancomycin biosynthesis
Katharina Woithe, Nina Geib, Odile Meyer, Tanja Wörtz, Katja Zerbe and John A. Robinson, Org. Biomol. Chem., 2008, 6, 2861
DOI: 10.1039/b805956j
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Reagent switchable stereoselective (1,2) mannoside mannosylation: OH-2 of mannose is a privileged acceptor
Katie J. Doores and Benjamin G. Davis, Org. Biomol. Chem., 2008, 6, 2692
DOI: 10.1039/b803999m
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Antioxidant activity of (+)-bergenin—a phytoconstituent isolated from the bark of Sacoglottis uchi Huber (Humireaceae)
Heitor A. De Abreu, Izandina Aparecida dos S. Lago, Gilmar P. Souza, Dorila Piló-Veloso, Hélio A. Duarte and Antônio Flávio de C. Alcântara, Org. Biomol. Chem., 2008, 6, 2713
DOI: 10.1039/b804385j
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A concise and straightforward total synthesis of (±)-salinosporamide A, based on a biosynthesis model
Nicholas P Mulholland, Gerald Pattenden and Iain A. S. Walters, Org. Biomol. Chem., 2008, 6, 2782
DOI: 10.1039/b803818j
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Trachycladindoles A–G: cytotoxic heterocycles from an Australian marine sponge, Trachycladus laevispirulifer
Robert J. Capon, Chongsheng Peng and Cedric Dooms, Org. Biomol. Chem., 2008, 6, 2765
DOI: 10.1039/b803455a
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First total synthesis of clausine L and pityriazole, a metabolite of the human pathogenic yeast Malassezia furfur
Ronny Forke, Anne Jäger and Hans-Joachim Knölker, Org. Biomol. Chem., 2008, 6, 2481
DOI: 10.1039/b805451g
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Concise synthesis of the tricyclic core of lycoposerramine S
Mark C. Elliott, Nahed N. E. El Sayed and James S. Paine, Org. Biomol. Chem., 2008, 6, 2611
DOI: 10.1039/b804664f
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Stereochemistry of eudesmane cation formation during catalysis by aristolochene synthase from Penicillium roqueforti
David J. Miller, Jiali Gao, Donald G. Truhlar, Neil J. Young, Veronica Gonzalez and Rudolf K. Allemann, Org. Biomol. Chem., 2008, 6, 2346
DOI: 10.1039/b804198a
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