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28 August 2008
A new Tamiflu screening method could help foil counterfeiters, say US scientists
Highlighting analytical science in China
27 August 2008
Read issue 9 of The Analyst which is a themed issue highlighting analytical science in China, guest edited by Mengsu Yang.
Contents list for The Analyst, issue 10, 2008
Front cover
Analyst, 2008, 133, 1285
DOI: 10.1039/b815703k
Contents and Chemical Technology
Analyst, 2008, 133, 1287
DOI: 10.1039/b815704a
Highlights
Recent developments in ambient ionization techniques for analytical mass spectrometry
Glenn A. Harris, Leonard Nyadong and Facundo M. Fernandez,
Analyst, 2008, 133, 1297
DOI: 10.1039/b806810k
With an ever-growing list of applications and new techniques, the development of ambient mass spectrometry shows little sign of slowing. Highlighted in this article are the recent advances in this promising field.
Optical nanosensors—smart tools in bioanalytics
Sergey M. Borisov and Ingo Klimant,
Analyst, 2008, 133, 1302
DOI: 10.1039/b805432k
The recent progress in the field of optical nanosensors. It gives an overview on materials, sensing schemes and applications of these smart tools in bioanalytics.
Critical Review
Plasmon-controlled fluorescence: a new paradigm in fluorescence spectroscopy
Joseph R. Lakowicz, Krishanu Ray, Mustafa Chowdhury, Henryk Szmacinski, Yi Fu, Jian Zhang and Kazimierz Nowaczyk,
Analyst, 2008, 133, 1308
DOI: 10.1039/b802918k
In this forward-looking overview we describe the near-field interactions of fluorophores with metallic nanostructures and how these effects can be used to enhance current measurements and to enable a new class of devices based on the manipulation of the excited-state energy of fluorophores in metallic nanostructures.
Communications
Genetic, genomic and physiological state studies on single-needle bio-electrosprayed human cells
Richard P. Hall, Caroline M. Ogilvie, Emma Aarons and Suwan N. Jayasinghe,
Analyst, 2008, 133, 1347
DOI: 10.1039/b806901h
This communication demonstrates no increased chromosome breakage or significant effects on cell nuclei following single-needle bio-electrospraying. These findings further extend the potential applications of bio-electrosprays.
On-chip Raman analysis of heterogeneous catalytic reaction in supercritical CO2: phase behaviour monitoring and activity profiling
Atsushi Urakawa, Franz Trachsel, Philipp Rudolf von Rohr and Alfons Baiker,
Analyst, 2008, 133, 1352
DOI: 10.1039/b808984c
Raman spectroscopy on a chip based Si/glass microreactor allows fast and simultaneous analysis of concentration profiles and phase behaviour of a heterogeneously catalyzed reaction at high pressure.
SERRS immunoassay for quantitative human CRP analysis
Fiona M. Campbell, Andrew Ingram, Paul Monaghan, Jon Cooper, Naveed Sattar, P. David Eckersall and Duncan Graham,
Analyst, 2008, 133, 1355
DOI: 10.1039/b808087a
SERRS has been used for the first time for the measurement of C-reactive protein (CRP) in an immunoassay. CRP, a biological marker for the diagnosis of infection and inflammation, is quantified in an ELISA using conventional reagents, but the usual colorimetric detection step is replaced by SERRS detection, offering improved sensitivity and potential for multiplexing analysis.
Papers
Microchip-based integration of cell immobilization, electrophoresis, post-column derivatization, and fluorescence detection for monitoring the release of dopamine from PC 12 cells
Michelle W. Li and R. Scott Martin,
Analyst, 2008, 133, 1358
DOI: 10.1039/b807093h
We describe the fabrication and evaluation of a multilayer microchip device that can be used to quantitatively measure the amount of catecholamines released from PC 12 cells immobilized within the same device.
Novel superparamagnetic core-shell molecular imprinting microspheres towards high selective sensing
Guiying Jin, Wei Li, Shaoning Yu, Youyuan Peng and Jilie Kong,
Analyst, 2008, 133, 1367
DOI: 10.1039/b802120a
Schematic representation of the preparation of MCSIMs
Isolation and pre-concentration of basic proteins in aqueous mixture via solid-phase extraction with multi-walled carbon nanotubes assembled on a silica surface
Zhuo Du, Yong-Liang Yu, Xiao-Rui Yan and Jian-Hua Wang,
Analyst, 2008, 133, 1373
DOI: 10.1039/b804347g
Separation and pre-concentration of basic proteins was achieved via solid-phase extraction with multi-walled carbon nanotubes (MWNTs) immobilized on a silica surface as a novel sorbent which was obtained by polyelectrolyte-assisted layer-by-layer (LBL) assembly.
Selective extraction and elution of weak bases by in-line solid-phase extraction capillary electrophoresis using a pH step gradient and a weak cation-exchange monolith
Jonathan R. E. Thabano, Michael C. Breadmore, Joseph P. Hutchinson, Cameron Johns and Paul R. Haddad,
Analyst, 2008, 133, 1380
DOI: 10.1039/b804805c
We have developed a strategy for the selective or universal adsorption and elution of weak bases for in-line solid-phase extraction–capillary electrophoresis using a weak cation-exchange monolith in conjunction with analyte focusing via an electroosmotic flow-mobilized pH gradient.
Ultratrace analysis of Antarctic snow samples by reaction cell inductively coupled plasma mass spectrometry using a total-consumption micro-sample-introduction system
Marco Grotti, Francesco Soggia and Josè Luis Todolì,
Analyst, 2008, 133, 1388
DOI: 10.1039/b804043e
A new procedure for the determination of ultratrace elements in snow samples has been developed, using quadrupole ICP-MS equipped with the dynamic reaction cell and a total-consumption micro-sample-introduction system
Utilization of spectral vector properties in multivariate chemometrics analysis of hyperspectral infrared imaging data for cellular studies
Suat-Teng Tan, Kejia Chen, Suyun Ong and Wee Chew,
Analyst, 2008, 133, 1395
DOI: 10.1039/b718458a
This paper demonstrates a suite of numerical techniques utilized in a concerted fashion for the efficacious multivariate chemometrics analysis of hyperspectral infrared imaging data of exfoliated oral mucosa cells.
A near-infrared fluorescent probe for lipid hydroperoxides in living cells
Ping Li, Bo Tang, Yanlong Xing, Puming Li, Guiwen Yang and Liang Zhang,
Analyst, 2008, 133, 1409
DOI: 10.1039/b802836b
A novel, near-infared fluorescent probe TCP (tricarbocyanine diphenylphosphine) was designed, synthesized and applied to detect lipid hydroperoxides within the membranes of living cells with high sensitivity and good selectivity.
Analysis of single blood cells for CSF diagnostics via a combination of fluorescence staining and micro-Raman spectroscopy
Michaela Harz, Michael Kiehntopf, Stephan Stöckel, Petra Rösch, Thomas Deufel and Jürgen Popp,
Analyst, 2008, 133, 1416
DOI: 10.1039/b716132h
Blood cell analysis in cerebrospinal fluid (CSF) is proposed, which provides the simultaneous determination of single blood cell differentiation via fluorescence staining and additional high specific molecular signatures via Raman spectroscopy.
Rapid and quantitative detection of the microbial spoilage in milk using Fourier transform infrared spectroscopy and chemometrics
Nicoletta Nicolaou and Royston Goodacre,
Analyst, 2008, 133, 1424
DOI: 10.1039/b804439b
Two infrared spectroscopy-based methods incorporating chemometrics were developed for the rapid and accurate enumeration of the microbial spoilage levels in whole, semi-skimmed and skimmed milk.
Biomechanical analysis of cancerous and normal cells based on bulge generation in a microfluidic device
Yu Chang Kim, Sang-Jin Park and Je-Kyun Park,
Analyst, 2008, 133, 1432
DOI: 10.1039/b805355c
Here we present a new biomechanical analysis method for discrimination between cancerous and normal cells using a microfluidic device. This study is the first demonstration showing the difference of bulge generation based on cytoskeleton quantity inside the cell.
Electronic integrated multisensor tongue applied to grape juice and wine analysis
Lia Moreno i Codinachs, Joachim P. Kloock, Michael J. Schöning, Antoni Baldi, Andrey Ipatov, Andrey Bratov and Cecilia Jiménez-Jorquera,
Analyst, 2008, 133, 1440
DOI: 10.1039/b801228h
A multisensor has been applied to grape juice and wine analysis: there is potential for distinguishing the grape variety and the vintage year, and also several sample parameters.
Towards quantitatively reproducible substrates for SERS
Roger M. Jarvis, Helen E. Johnson, Emma Olembe, Arunkumar Panneerselvam, Mohammad A. Malik, Mohammad Afzaal, Paul O'Brien and Royston Goodacre,
Analyst, 2008, 133, 1449
DOI: 10.1039/b800340h
Objective assessment of the batch-to-batch reproducibility of SERS spectra acquired from a range of colloidal substrates
Back matter
Analyst, 2008, 133, 1453
DOI: 10.1039/b815705g
Back cover
Analyst, 2008, 133, 1455
DOI: 10.1039/b815706p
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