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Instant insight: Disease snapshots
24 July 2008
Hye Jin Lee and Robert Corn look at the latest breakthroughs in the use of microarray technology for the fast detection of cancer
New Analyst Scientific Editor, Reviews
04 July 2008
RSC Publishing is delighted to announce the appointment of Professor Duncan Graham as the new Analyst Scientific Editor for Reviews.
Record breaking impact for The Analyst!
26 June 2008
Newly released ISI citation data show The Analyst's impact factor higher than ever at 3.553.
Contents list for The Analyst, issue 8, 2008
Front cover
Analyst, 2008, 133, 965
DOI: 10.1039/b811293m
Inside front cover
Analyst, 2008, 133, 966
DOI: 10.1039/b811294k
Contents and Chemical Technology
Analyst, 2008, 133, 967
DOI: 10.1039/b811295a
Highlights
Microarray methods for protein biomarker detection
Hye Jin Lee, Alastair W. Wark and Robert M. Corn,
Analyst, 2008, 133, 975
DOI: 10.1039/b717527b
The application of microarray-based detection platforms for the high-throughput analysis of protein biomarkers found in easily accessible biological samples such as serum holds significant opportunities for improving patient care. Here, we highlight some recent developments and challenges in this endeavor.
Recent advances in DNA sensors
Serge Cosnier and Pascal Mailley,
Analyst, 2008, 133, 984
DOI: 10.1039/b803083a
This review points out emerging trends over the past three years concerning the immobilization of DNA and the transduction of the hybridization step.
Perspective
Standard additions: myth and reality
Stephen L. R. Ellison and Michael Thompson,
Analyst, 2008, 133, 992
DOI: 10.1039/b717660k
A generalised model of an analytical system is used to derive the uncertainty involved in the method of standard additions and to show that, when the method is executed optimally, there is no noteworthy loss of precision.
Communications
Separation-free detection of nuclear factor kappa B with double-stranded molecular probes
Zhaohui Wang, Vinay Gidwani, Donna D. Zhang and Pak Kin Wong,
Analyst, 2008, 133, 998
DOI: 10.1039/b809113g
This paper reports a simple, rapid molecular binding scheme for the detection and quantification of the transcription factor nuclear factor kappa B and other DNA binding proteins without any separation or immobilization step.
Ion-sensitive field effect transistors using carbon nanotubes as the transducing layer
Cristina C. Cid, Jordi Riu, Alicia Maroto and F. Xavier Rius,
Analyst, 2008, 133, 1001
DOI: 10.1039/b800862k
A new type of ion-sensitive field effect transistor (ISFET) is presented. This ISFET is based on a network of carbon nanotubes covered by a PVC membrane selective to potassium ions. Our configuration makes an external reference electrode unnecessary.
Carbon nanotube field effect transistors for the fast and selective detection of human immunoglobulin G
Cristina C. Cid, Jordi Riu, Alicia Maroto and F. Xavier Rius,
Analyst, 2008, 133, 1005
DOI: 10.1039/b805301b
A carbon nanotube field effect transistor (CNTFET) for the selective detection of human immunoglobulin G (HIgG) is presented. Nanomolar concentrations of HIgG are detected with this rapid-to-build, label-free and reagentless device.
Enzyme shadowing: using antibody–enzyme dually-labeled magnetic particles for fast bacterial detection
Eva Baldrich and Francesc Xavier Muñoz,
Analyst, 2008, 133, 1009
DOI: 10.1039/b805536j
This work demonstrates that simultaneous incorporation of capture and reporter biocomponents onto the sensing surface is possible and provides sandwich assays that are extremely fast and easy to carry out.
Papers
A double-stranded molecular probe for homogeneous nucleic acid analysis
Daniel Meserve, Zhaohui Wang, Donna D. Zhang and Pak Kin Wong,
Analyst, 2008, 133, 1013
DOI: 10.1039/b804853c
A double-stranded molecular probe has been designed and optimized for the detection of single nucleotide mismatches in a single step without any separation step or measurement of melting profile.
The analytical utility of thermally desorbed polydimethylsilicone membranes for in-vivo sampling of volatile organic compounds in and on human skin
S. Riazanskaia, G. Blackburn, M. Harker, D. Taylor and C. L. P. Thomas,
Analyst, 2008, 133, 1020
DOI: 10.1039/b802515k
A new and highly sensitive thermal desorption methodology for profiling volatile organic compounds in and on human skin yields reproducible data. The complicated interactions of bio-kinetics, physical chemistry and micro-biology require careful experimental design and sample handling.
Spectroscopic and quantitative analysis of spiroorthoester synthesis by two-dimensional correlation and multivariate curve resolution methods of NIR data
Nicolás Spegazzini, Itziar Ruisánchez, M. Soledad Larrechi, Virginia Cádiz and Judit Canadell,
Analyst, 2008, 133, 1028
DOI: 10.1039/b802161a
Quantitative analysis of spiroorthoester synthesis that includes several competitive reactions was performed using two-dimensional correlation and multivariate curve resolution-alternating least squares using data NIR spectroscopy.
SPR imaging for label-free multiplexed analyses of DNA N-glycosylase interactions with damaged DNA duplexes
Christelle Corne, Jean-Bernard Fiche, Didier Gasparutto, Valérie Cunin, Emmanuel Suraniti, Arnaud Buhot, Julia Fuchs, Roberto Calemczuk, Thierry Livache and Alain Favier,
Analyst, 2008, 133, 1036
DOI: 10.1039/b801086b
We report SPR imaging-based assays to analyze enzymatic DNA repair activities. This miniaturized and multiplexed bioanalytical approach provides a new powerful tool to develop screening platforms to search for new DNA repair activity modulators.
Self Organising Maps for distinguishing polymer groups using thermal response curves obtained by dynamic mechanical analysis
Gavin R. Lloyd, Richard G. Brereton and John C. Duncan,
Analyst, 2008, 133, 1046
DOI: 10.1039/b715390b
Self Organising Maps are applied to thermo-mechanical profiles of polymers characterised by type, group and grade and several different approaches for visualisation are described.
Towards multifunctional microelectrode arrays
Francisco. A. Aguiar, Mark. C. Rosamond, David Wood and Ritu Kataky,
Analyst, 2008, 133, 1060
DOI: 10.1039/b802475h
Identification of defective clusters of sensors and multi-analyte analyses in a single sensor array platform comprised of microelectrodes can be achieved by flexible multiplexing of groups of microelectrodes.
Rapid hydrocarbon analysis using a miniature rectilinear ion trap mass spectrometer
Ewa Sokol, Kathleen E. Edwards, Kuangnan Qian and R. Graham Cooks,
Analyst, 2008, 133, 1064
DOI: 10.1039/b805813j
A hand-held mass spectrometer can be used to identify and quantify a variety of compounds of interest in the petroleum and petrochemical industry, including trace organics in air and water, odiferous compounds, and naphtha distillates.
Fullerene-based electrochemical buffer layer for ion-selective electrodes
Maria Fouskaki and Nikos Chaniotakis,
Analyst, 2008, 133, 1072
DOI: 10.1039/b719759d
C60 fullerene is used as electrochemical mediator for the development of an all-solid-state ion-selective electrodes (ISEs). The unique electrochemical characteristics of the fullerenes allow for the facile ion-to-electron transduction across the ionically active polymeric ion-selective membrane and the electrochemically active glassy carbon transducer, providing a stable and reversible solid-state ISE system.
Carbon nanotubes as sorbents for the gas phase preconcentration of semivolatile organics in a microtrap
Chaudhery Mustansar Hussain, Chutarat Saridara and Somenath Mitra,
Analyst, 2008, 133, 1076
DOI: 10.1039/b801415a
We report the application of carbon nanotubes (CNTs) as the high performance sorbents in the fabrication of a microtrap. The high aspects ratios of CNTs lead to high sorption capacity, and their nonporous nature reduces mass transfer resistance, which allows easy desorbability. Together, these extend the range of compounds that can be analyzed.
Self-encapsulation of oxidases as a basic approach to tune the upper detection limit of amperometric biosensors
Arunas Ramanavicius, Asta Kausaite and Almira Ramanaviciene,
Analyst, 2008, 133, 1083
DOI: 10.1039/b801501e
A new, basic procedure for the tuning of some analytical parameters of enzymatic biosensors that are based on hydrogen peroxide-producing oxido-reductases is described.
Multi-analyte sensing: a chemometrics approach to understanding the merits of electrode arrays versus single electrodes
Diako Ebrahimi, Edith Chow, Justin J. Gooding and David B. Hibbert,
Analyst, 2008, 133, 1090
DOI: 10.1039/b804811h
An array of peptide-modified electrodes for sensing metal ions gives a better calibration than a single electrode modified with all the peptides when there is substantial overlap of voltammetric peaks.
Electrochemical impedance spectroscopy and surface plasmon resonance studies of DNA hybridization on gold/SiOx interfaces
Maël Manesse, Valerie Stambouli, Rabah Boukherroub and Sabine Szunerits,
Analyst, 2008, 133, 1097
DOI: 10.1039/b804825h
The use of Au/SiOx interfaces for the investigation of DNA hybridization using, simultaneously, electrochemical impedance spectroscopy (EIS) and surface plasmon resonance (SPR) is demonstrated.
Development of a contactless conductivity detector cell for 1.6 mm O.D. (1/16th inch) HPLC tubing and micro-bore columns with on-column detection
Eoin Gillespie, Damian Connolly, Mirek Macka, Peter Hauser and Brett Paull,
Analyst, 2008, 133, 1104
DOI: 10.1039/b803038c
A contactless conductivity cell for use with 1/16th inch O.D. tubing and on-column detection of ionic species has been developed.
Back cover
Analyst, 2008, 133, 1111
DOI: 10.1039/b811296g
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