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Chemical Communications

Urgent high quality communications from across the chemical sciences.



Hot Articles



A molecular model of a diphenyl urea bound to G4 DNA

Quadruplex binding clicks into place

06 October 2008

Ureas that shun the double helix for four-stranded DNA could lead to new anticancer drugs, say UK scientists



A molecular beacon that incorporates components of an artificially expanded genetic information system (AEGIS) in its stem is shown not to be opened by unwanted stem invasion by adventitious standard DNA. This should improve the darkness of the beacon in real-world applications

Hot article: Improved darkness of molecular beacon

02 October 2008

A new tool that reduces the detection of non-targeted DNA has been designed by researchers from the US.



Cycloaddition product for reaction of transition metal hydrazides with alkynes

Hot article: Cycloaddition of TM Hydrazides

30 September 2008

A collaboration from the UK, Australia and France have synthesised cycloaddition products of transition metal hydrazides with alkynes and heteroalkynes.



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Hot article: Star polymers via a thiol-ene click reaction

29 September 2008

US researchers have synthesised three-arm star polymers by thiol-ene click reactions of RAFT-generated polymers and a trifunctional acrylate.



Charge density map

Cracking charge density

25 September 2008

UK scientists answer the all important question: how many electrons are there on each atom in a molecule?



Alpha and Beta conjugated bis-aptamers against thrombin act as bidentate glue for the self-assembly of thrombin nanowires. Mixing the bidentate aptamer with a tripoded tridentate alpha aptamer constructs yields branched thrombin nanowire structures

Hot article: Aptamer glues Thrombin into nanostructures

25 September 2008

Scientists in Israel describe the self-assembly of thrombin nanowires using alpha and beta bis-aptamers.



Using N,N

Hot article: Silica micro-tube networks

24 September 2008

Scientists in Beijing have prepared functional silica micro-tube networks that could have applications in molecular imprinting, catalysis or micro-reactors.



Two isomorphous Co(II) and Mn(II) three-dimensional coordination polymers with tetrazolate-5-carboxylate as magnetic mediator exhibit an unprecedented 3,4-connected self-penetrating net topology.

Hot article: Unprecedented self-penetrating net

24 September 2008

Scientists in China have prepared new metal-organic materials that are magnetic and exhibit an unprecedented 3,4-connected self-penetrating net.



The layered rare earth hydroxide crystallites trapped at the hexane/water interface could be transferred onto a substrate to produce an oriented monolayer film, exhibiting excellent anion-exchange and photoluminescence properties.

Hot article: Photoluminescent well-organised films

22 September 2008

Scientists in Japan describe the film fabrication of layered rare earth hydroxides that show anion-exchange and photoluminescent properties.



Nitrogen functional groups on carbon nanotubes

Hot article: Designing basic catalysts

22 September 2008

Scientists from Germany have investigated the structure and stability of N-functionalised nanotubes, to help create greener basic catalysts.



Nano-cluster containing Molybdenum and Vanadium identified in solution using cryospray mass spectrometry

Hot article: Cryospray Mass Spectrometry identifies a unique nanostructure in solution

19 September 2008

A collaboration of scientists from the UK, Greece and the US have used self-assembly in solution to create a new class of nano-cluster



Single molecule fluorescence microscopy is combined with electrochemistry

Hot article: Powerful new combined technique

19 September 2008

US Scientists have combined electrochemistry and single-molecular fluorescence microscopy to study electron transfer processes at the single-molecule level.



Marine sponge

Hot Article: Marine natural product synthesis

18 September 2008

A concise total synthesis of the marine macrolide (+)-neopeltolide has been completed by scientists in the UK.



P,N-hetercyclic carbene

Hot article: P,N-heterocyclic carbenes

18 September 2008

US scientists have prepared conjugate acids of cyclic P,N-carbenes, as potential ligands for transition metal catalysts



A potent anti-MRSA molecule

Inhibiting the spread of superbugs

11 September 2008

UK chemists have found a small molecule with the potential to overcome the spread of the deadly infection MRSA



Nickel-ruthenium complex

Designing natural product hybrids with anticancer activity

04 September 2008

A potent hybrid of two anticancer natural products has been designed and synthesised by UK chemists.



Gold nanoprobes

Probing mercury contamination

02 September 2008

Detecting mercury pollution could become a lot easier, thanks to a new visual technique developed by scientists in China



planet Titan

A Titan discovery

29 August 2008

European researchers step closer to explaining hydrocarbon formation on Saturn's largest moon.



TEM image of the bacteria@Au nanocomposites

Hot article: E-coli used to help kill cancer

29 August 2008

Scientists from Taiwan have successfully combined E-coli with gold nanoparticles to help fight cancer.



Substrate bound in the active site of hen egg white lysozyme

Rewriting the biochemistry textbooks

22 August 2008

Calculations validate alternative to a much-published enzyme mechanism



Bandage

Knockout nanoparticles fight infection

20 August 2008

Septicaemia causing bacteria take a blow from two different types of antibacterial nanoparticles



The petrobactin siderophore

Revising the route to a stealthy siderophore

19 August 2008

Surprising result reveals details of potential enzyme target in the fight against anthrax



lemons

Sweet smell of success

18 August 2008

German scientists have used an ionic liquid coating on a hydrogenation catalyst to make sweet smelling chemicals



Chiral proton catalyst

Hot article: Synthesis of amino acid surrogates

14 August 2008

A straightforward route to organophosphorus compounds has been devised by US Scientists.



Serum albumin

New twist on protein binding

13 August 2008

A fortuitous discovery has led to a new type of probe for protein interactions that could find use in cellular imaging



The Pd-catalysed asymmetric intramolecular - arylation of amide enolates containing heteroatom substituents gives chiral 3-alkoxy or 3-amino-oxindoles in high yield and enantiomeric purity. Key to this success is a new chiral N-heterocyclic carbene ligand.

Hot article: New synthetic route to oxindoles

07 August 2008

Scientists in Switzerland and the UK have prepared oxindoles in high yield using a new Pd/N-heterocyclic carbene catalyst.