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Omega comes first for brain imaging
02 November 2009
Remote-controlled miniature valves designed by US scientists can deliver tracers into the brain.
Acidity regulation in microfluidic channels
30 October 2009
Controlling pH in microfluidics could allow the activity of single enzymes to be measured, say Dutch scientists.
Chips & Tips: Plug-and-play reservoirs for microfluidics
28 October 2009
Christopher Y Wong and Georgian Ionut Ciobanu demonstrate plug-and-play reservoirs for microfluidics
Chips & Tips: A novel method for fabrication of reusable microfluidic interconnects
28 October 2009
V T Remcho and co-workers present a novel method for fabrication of reusable microfluidic interconnects
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Contents list for Lab on a Chip, issue 22, 2009
Front cover
Lab Chip, 2009, 9, 3165
DOI: 10.1039/B921043C
Inside front cover
Lab Chip, 2009, 9, 3166
DOI: 10.1039/B921044J
Contents and Chemical Technology
Lab Chip, 2009, 9, 3167
DOI: 10.1039/B921045H
Highlight
Research Highlights
Lab Chip, 2009, 9, 3175
DOI: 10.1039/b919968n
Petra Dittrich reviews the current literature in miniaturisation and related technologies.
Papers
A robust electrical microcytometer with 3-dimensional hydrofocusing
Nicholas Watkins, Bala Murali Venkatesan, Mehmet Toner, William Rodriguez and Rashid Bashir,
Lab Chip, 2009, 9, 3177
DOI: 10.1039/b912214a
3-Dimensional (3D) hydrodynamic focusing using a single microfluidics layer enhances the accuracy of electrical analysis of cellular populations, especially CD4+ T lymphocytes for AIDS diagnostics on a chip.
Towards a human-on-chip: Culturing multiple cell types on a chip with compartmentalized microenvironments
Chi Zhang, Ziqing Zhao, Nur Aida Abdul Rahim, Danny van Noort and Hanry Yu,
Lab Chip, 2009, 9, 3185
DOI: 10.1039/b915147h
A 4-channel 3D cell-culture chip to mimic the blood/drug interactions with liver, lung, kidney and fat: systemic circulation interacts with organs preserving local organ environments.
A continuous high-throughput bioparticle sorter based on 3D traveling-wave dielectrophoresis
I-Fang Cheng, Victoria E. Froude, Yingxi Zhu, Hsueh-Chia Chang and Hsien-Chang Chang,
Lab Chip, 2009, 9, 3193
DOI: 10.1039/b910587e
A high throughput continuous bio-particle sorter based on 3D traveling-wave dielectrophoresis (twDEP) is presented. Sorting is achieved by sustained twDEP particle force normal to the continuous through-flow and applied over the entire chip by a single 3D electrode array operated at an AC frequency.
Microinjection in a microfluidic format using flexible and compliant channels and electroosmotic dosage control
Arash Noori, P. Ravi Selvaganapathy and Joanna Wilson,
Lab Chip, 2009, 9, 3202
DOI: 10.1039/b909961a
A simple one degree of freedom microinjection device for embryos is demonstrated. The device uses compliant channel for actuation and electroosmotic flow for injection of reagents.
Enhancing DNA hybridization kinetics through constriction-based dielectrophoresis
Nathan Swami, Chia-Fu Chou, Venkatraman Ramamurthy and Vasudha Chaurey,
Lab Chip, 2009, 9, 3212
DOI: 10.1039/b910598k
Constrictions to enhance focussing fields during dielectrophoresis were applied to pre-concentrate target DNA for enhancement of hybridization kinetics.
Integration and application of vitrified collagen in multilayered microfluidic devices for corneal microtissue culture
Christopher M. Puleo, Winnette McIntosh Ambrose, Toshiaki Takezawa, Jennifer Elisseeff and Tza-Huei Wang,
Lab Chip, 2009, 9, 3221
DOI: 10.1039/b908332d
This paper describes the fabrication and application of microfluidic devices containing collagen vitrigel (CV) used as both a functional and sacrificial cell growth substrate for the development of corneal microtissue patches.
A light-induced dielectrophoretic droplet manipulation platform
Sung-Yong Park, Sheraz Kalim, Caitlin Callahan, Michael A. Teitell and Eric P. Y. Chiou,
Lab Chip, 2009, 9, 3228
DOI: 10.1039/b909158k
We report on a light-actuated, droplet based microfluidic platform enabling two-dimensional (2D) droplet manipulation on an open chamber with a single-side, featureless photoconductive surface. We have demonstrated light-actuated droplet manipulation functions including 2D droplet transport, merging, mixing, and multidroplet processing.
Agarose microwell based neuronal micro-circuit arrays on microelectrode arrays for high throughput drug testing
Gyumin Kang, Ji-Hye Lee, Chang-Soo Lee and Yoonkey Nam,
Lab Chip, 2009, 9, 3236
DOI: 10.1039/b910738j
An agarose microwell based micro-neuronal circuit array coupled with a planar microelectrode array is proposed for a novel multi-well type neuron-based biosensing platform.
Microfluidic system with integrated electroosmotic pumps, concentration gradient generator and fish cell line (RTgill-W1)—towards water toxicity testing
Tomasz Glawdel, Caglar Elbuken, Lucy E. J. Lee and Carolyn L. Ren,
Lab Chip, 2009, 9, 3243
DOI: 10.1039/b911412m
This study presents a new integrated microfluidic system coupled with a fish cell line for toxicity testing of drinking water supplies.
A micro surface tension alveolus (MISTA) in a glass microchip
Xing Yue (Larry) Peng, Lan-Qin Wu, Na Zhang, Li-Dan Hu, You Li, Wen-Juan Li, Dong-Hui Li, Ping Huang and Yong-Liang Zhou,
Lab Chip, 2009, 9, 3251
DOI: 10.1039/b913112d
A non-membrane micro surface tension alveolus (MISTA) in a glass microchip controlled the micro scale gradients of gases. The hemoglobin (Hb) visualized dissolved O2 and CO2 as moving micro colour rings from a MISTA.
Multi-curvature liquid meniscus in a nanochannel: Evidence of interplay between intermolecular and surface forces
Pilnam Kim, Ho-Young Kim, Jae Kwan Kim, Günter Reiter and Kahp Y. Suh,
Lab Chip, 2009, 9, 3255
DOI: 10.1039/b911271e
The formation of a multi-curvature meniscus is presented when a low-viscosity liquid precursor is introduced inside a rectangular nanochannel followed by photo-polymerization under the partial wetting regime.
On-chip immuno-agglutination assay with analyte capture by dynamic manipulation of superparamagnetic beads
Y. Moser, T. Lehnert and M. A. M. Gijs,
Lab Chip, 2009, 9, 3261
DOI: 10.1039/b907724c
We present a magnetic bead-based immuno-agglutination assay performed on-chip. Dynamic actuation of a confined bead plug is used for analyte capture in a microchannel. A simple detection method is discussed.
Electric field directed assembly of high-density microbead arrays
Kristopher D. Barbee, Alexander P. Hsiao, Michael J. Heller and Xiaohua Huang,
Lab Chip, 2009, 9, 3268
DOI: 10.1039/b912876j
We report a method for rapid, electric field directed assembly of high-density protein-conjugated microbead arrays. Filling efficiencies greater than 99.9% have been demonstrated across wafer-scale arrays with densities as high as 69 million beads per cm2.
Lab-on-a-chip for botulinum neurotoxin a (BoNT-A) activity analysis
Steven Sun, Miguel Ossandon, Yordan Kostov and Avraham Rasooly,
Lab Chip, 2009, 9, 3275
DOI: 10.1039/b912097a
Functional elements of multi-channel LOC system for botulinum neurotoxin A activity analysis.
Controllable preparation of microscale tubes with multiphase co-laminar flow in a double co-axial microdevice
Wenjie Lan, Shaowei Li, Yangcheng Lu, Jianhong Xu and Guangsheng Luo,
Lab Chip, 2009, 9, 3282
DOI: 10.1039/b913247c
A simple method for the fabrication of microscale polymer tubes in a double co-axial microchannel device is presented. This technology has the potential to generate hollow fiber membranes for applications in separation and reaction processes.
Microfluidics with on-line dynamic light scattering for size measurements
Fanny Destremaut, Jean-Baptiste Salmon, Ling Qi and Jean-Paul Chapel,
Lab Chip, 2009, 9, 3289
DOI: 10.1039/b906514h
This work presents a thorough investigation on the feasibility of on-line Dynamic Light Scattering (DLS) experiments in microfluidic flows. A chip for in situ colloidal size measurement is described.
Technical Notes
SNP genotyping of unpurified PCR products by sandwich-type affinity electrophoresis on a microchip with programmed autonomous solution filling
Akira Inoue, Aishan Han, Kimiko Makino, Kazuo Hosokawa and Mizuo Maeda,
Lab Chip, 2009, 9, 3297
DOI: 10.1039/b910946c
We describe rapid SNP genotyping by sandwich-type affinity electrophoresis on a PDMS–glass microchip. Prior to the electrophoresis, the necessary solutions were autonomously and precisely filled into specific regions of the microchannel by air dissolution into PDMS and two kinds of passive stop valves.
Multidimensional modular microfluidic system
Po Ki Yuen, Jody T. Bliss, Christopher C. Thompson and Richard C. Peterson,
Lab Chip, 2009, 9, 3303
DOI: 10.1039/b912295h
We present an extension of our previous work on a genuinely plug-n-play modular microfluidic system for designing and building customized multidimensional microfluidic systems. Also, the feature of a circuit board and alignment pins were added for better system integration and system design flexibility.
Fabricating small-scale, curved, polymeric structures with convex and concave menisci through interfacial free energy equilibrium
Chao-Min Cheng, Koji Matsuura, I-Jan Wang, Yuka Kuroda, Philip R. LeDuc and Keiji Naruse,
Lab Chip, 2009, 9, 3306
DOI: 10.1039/b910826b
Small-scale, PDMS-based, convex and concave structures can be fabricated through controlling interfacial free energy equilibrium.
Back matter
Lab Chip, 2009, 9, 3310
DOI: 10.1039/B921046F
Back cover
Lab Chip, 2009, 9, 3311
DOI: 10.1039/B921047B
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