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Contents list for Molecular BioSystems, issue 9, 2008
Front cover
Mol. BioSyst., 2008, 4, 873
DOI: 10.1039/b813052n
Contents and Chemical Biology
Mol. BioSyst., 2008, 4, 875
DOI: 10.1039/b813053c
Highlights
Quorum sensing by 2-alkyl-4-quinolones in Pseudomonas aeruginosa and other bacterial species
Jean-Frédéric Dubern and Stephen P. Diggle,
Mol. BioSyst., 2008, 4, 882
DOI: 10.1039/b803796p
Enhanced HTML article available
The biological functions of PQS produced by Pseudomonas aeruginosa.
Protein kinase CK2 as a druggable target
Stefania Sarno and Lorenzo A. Pinna,
Mol. BioSyst., 2008, 4, 889
DOI: 10.1039/b805534c Enhanced HTML article available
This contribution highlights the implication of protein kinase CK2 in creating a cellular environment favourable to the development and potentiation of the tumor phenotype. The pharmacological potential of cell permeable CK2 specific inhibitors is discussed.
Small molecule enhancers of autophagy for neurodegenerative diseases
Sovan Sarkar and David C. Rubinsztein,
Mol. BioSyst., 2008, 4, 895
DOI: 10.1039/b804606a Enhanced HTML article available
Autophagy is a major degradation pathway for various aggregate-prone proteins associated with neurodegenerative disorders. Enhancing autophagy with small molecules may be a possible therapeutic strategy for such diseases where the mutant proteins are autophagy substrates.
Surveying the damage: the challenges of developing nucleic acid biomarkers of inflammation
Junghyun Son, Bo Pang, Jose L. McFaline, Koli Taghizadeh and Peter C. Dedon,
Mol. BioSyst., 2008, 4, 902
DOI: 10.1039/b719411k Enhanced HTML article available
Chronic inflammation and human disease may be linked by damage to biomolecules such as DNA and RNA, with the spectrum of products reflecting the chemistry of phagocyte-generated reactive species.
Review Articles
Targeting transcription factors for therapeutic benefit
Paul Brennan, Rossen Donev and Saman Hewamana,
Mol. BioSyst., 2008, 4, 909
DOI: 10.1039/b801920g Enhanced HTML article available
Recent developments in chemical biology and clinical medicine have led to the development of new ways of targeting transcription factors including blocking transcription factor dimerisation, targeting specific DNA sequences and DNA decoys. These agents have the potential to be valuable agents for the treatment of cancer.
Linking the kinome and phosphorylome—a comprehensive review of approaches to find kinase targets
Richelle Sopko and Brenda J. Andrews,
Mol. BioSyst., 2008, 4, 920
DOI: 10.1039/b801724g Enhanced HTML article available
Conceptual basis for a genetic scenario enabling kinase substrate identification
Communication
Peptide mass fingerprinting using isotopically encoded photo-crosslinking amino acids
Bryan J. Wilkins, Kelly A. Daggett and T. Ashton Cropp,
Mol. BioSyst., 2008, 4, 934
DOI: 10.1039/b801512k Enhanced HTML article available
When isotopically labelled photo-crosslinking amino acids are site-specifically incorporated into proteins, in combination with the corresponding non-labeled analogue, cross-linked tryptic peptides are easily identified in mass spectra via characteristic 
doublet
patterns.
Papers
Transcriptomic analysis of Saccharomyces cerevisiae physiology in the context of galactose assimilation perturbations
C. Syriopoulos, A. Panayotarou, K. Lai and Maria I. Klapa,
Mol. BioSyst., 2008, 4, 937
DOI: 10.1039/b718732g Enhanced HTML article available
The full-genome transcriptomic study of Saccharomyces cerevisiae; glucose- and galactose-grown wild-type and glucose-grown gal7-deficient physiologies indicated the latter to be correlated to glucose derepressive conditions; galactose assimilation has to be studied within the entire carbon source sensing and regulation machinery.
Fluorescent resonance energy transfer (FRET) based detection of a multiplex ligation-dependent probe amplification assay (MLPA) product
V. Cengiz Ozalp, Anders O. H. Nygren and Ciara K. O
Sullivan,
Mol. BioSyst., 2008, 4, 950
DOI: 10.1039/b802382d Enhanced HTML article available
A fluorescent resonance energy transfer (FRET)-based hybridization assay for detecting multiplex ligation-dependent probe amplification (MLPA), demonstrating the possibility of combining MLPA with microarrays for the detection of multiple mutations in a single reaction tube.
Back cover
Mol. BioSyst., 2008, 4, 955
DOI: 10.1039/b813055h
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