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Editorial Board member, Madan Babu, wins an EMBO Young Investigator Award
06 November 2009
Madan Babu was one of 17 scientists chosen this year as winners of the EMBO Young Investigators award
Sticky polymers for wound healing
23 October 2009
Promise for tissue regeneration therapy as temperature-responsive gels help move cells from A to B
Culture clash for good and bad bacteria
23 October 2009
Lab-on-a-chip that co-cultures cells from the human gut offers screening for probiotics
Issue 11 of NPR: themed issue on genomics
22 October 2009
Issue 11 of NPR contains 6 reviews focussing on the fascinating insights being provided into plant and bacterial secondary metabolism by genome sequencing and genome mining
Contents list for Molecular BioSystems, issue 11, 2009
Front cover
Mol. BioSyst., 2009, 5, 1249
DOI: 10.1039/b920312p
Inside front cover
Mol. BioSyst., 2009, 5, 1250
DOI: 10.1039/b920313n
Contents and Highlights in Chemical Biology
Mol. BioSyst., 2009, 5, 1251
DOI: 10.1039/b920314c
Profile
Emerging investigators 2009
Mol. BioSyst., 2009, 5, 1261
DOI: 10.1039/b919131n
Profiling contributors who were invited to submit their work for the Molecular BioSystems 2009 Emerging Investigators issue but who didn
t make the dedicated issue in time (See: www.molecularbiosystems.org/ei2009).
Reviews
Combining radiation, immunotherapy, and antiangiogenesis agents in the management of cancer: the Three Musketeers or just another quixotic combination?
Mitchell Kamrava, Michael B. Bernstein, Kevin Camphausen and James W. Hodge,
Mol. BioSyst., 2009, 5, 1262
DOI: 10.1039/b911313b
Enhanced HTML article available
This review examines preclinical and clinical data on the interaction between immunotherapy and radiation, and discusses the potential synergy between these two modalities and angiogenesis inhibitors.
Metabolic tagging and purification of nascent RNA: implications for transcriptomics
Caroline C. Friedel and Lars Dölken,
Mol. BioSyst., 2009, 5, 1271
DOI: 10.1039/b911233b Enhanced HTML article available
Throughout the last few years methods have been developed for metabolic tagging and purification of nascent RNA. In this article, we review these experimental procedures and discuss their implications for large-scale gene expression profiling.
Molecular probes for the in vivo imaging of cancer
Raphael Alford, Mikako Ogawa, Peter L. Choyke and Hisataka Kobayashi,
Mol. BioSyst., 2009, 5, 1279
DOI: 10.1039/b911307j Enhanced HTML article available
We overview the recent development of chemical reagents for the use of various molecular imaging modalities, including nuclear imaging, optical imaging, and magnetic resonance imaging (MRI).
Artificial assembly of a minimal cell
Giovanni Murtas,
Mol. BioSyst., 2009, 5, 1292
DOI: 10.1039/b906541e Enhanced HTML article available
It is becoming realistic to construct artificial cells, starting from a minimal cell assembly, and deliver cell-like bioreactors to synthesize pure proteins/enzymes or isolate single pathways
Communications
Simultaneous glycoproteomics on the basis of structure using ion mobility-mass spectrometry
Larissa S. Fenn and John A. McLean,
Mol. BioSyst., 2009, 5, 1298
DOI: 10.1039/b909745g Enhanced HTML article available
Simultaneous glycoproteomic characterization using rapid (
s to ms) structural separations provided by ESI- and MALDI-ion mobility-mass spectrometry (IM-MS) is described.
How stable are 1,2-dihydro-1,2-azaborines toward water and oxygen?
Ashley N. Lamm and Shih-Yuan Liu,
Mol. BioSyst., 2009, 5, 1303
DOI: 10.1039/b904120f Enhanced HTML article available
The stability of 1,2-dihydro-1,2-azaborines toward oxygen and water was investigated as a function of their ring substituents. While generally 1,2-dihydro-1,2-azaborines are compatible with water, their stability toward oxygen is dependent on the boron and the C(3) substituents. We find that electron-withdrawing groups enhance the heterocycles ability to resist oxidative degradation.
In vivo siRNA delivery with dendritic poly(L-lysine) for the treatment of hypercholesterolemia
Kazuto Watanabe, Mariko Harada-Shiba, Akira Suzuki, Risa Gokuden, Ryohsuke Kurihara, Yusuke Sugao, Takeshi Mori, Yoshiki Katayama and Takuro Niidome,
Mol. BioSyst., 2009, 5, 1306
DOI: 10.1039/b900880b Enhanced HTML article available
Intravenous delivery of a complex of apolipoprotein B-specific siRNA with a sixth-generation dendritic poly(L-lysine) (KG6) into mice resulted in a significant reduction of serum low-density lipoprotein cholesterol.
Papers
DNA intercalation of methylene blue and quinacrine: new insights into base and sequence specificity from structural and thermodynamic studies with polynucleotides
Maidul Hossain and Gopinatha Suresh Kumar,
Mol. BioSyst., 2009, 5, 1311
DOI: 10.1039/b909563b Enhanced HTML article available
This article conclusively delineates the base and sequence specificity and energetics in the DNA interaction of quinacrine and methylene blue employing various biophysical techniques.
Arginine-based PNA microarrays for APOE genotyping
Alessandro Calabretta, Tullia Tedeschi, Gabriella Di Cola, Roberto Corradini, Stefano Sforza and Rosangela Marchelli,
Mol. BioSyst., 2009, 5, 1323
DOI: 10.1039/b909912n Enhanced HTML article available
Four PNAs complementary to the APOE gene tracts containing SNPs related to Alzheimers disease, embedding one monomer based on two arginine units, were used to build microarrays able to easily discriminate matched and single-point mismatched DNA targets.
Tumor-specific protein human galectin-1 interacts with anticancer agents
Sabato DAuria, Lidia Petrova, Constance John, George Russev, Antonio Varriale and Vanya Bogoeva,
Mol. BioSyst., 2009, 5, 1331
DOI: 10.1039/b905921k Enhanced HTML article available
The present work shows a novel binding activity of the tumor specific lectin—recombinant human galectin-1 (hGal-1)—to three porphyrin compounds: (1) Zn-porphyrin (ZnTPPS); (2) Mn-porphyrin and (3) Au-porphyrin. These compounds are widely applied in the photodynamic therapy of cancer (PDT).
Global analysis of the yeast osmotic stress response by quantitative proteomics
Boumediene Soufi, Christian D. Kelstrup, Gabriele Stoehr, Florian Fröhlich, Tobias C. Walther and Jesper V. Olsen,
Mol. BioSyst., 2009, 5, 1337
DOI: 10.1039/b902256b Enhanced HTML article available
Here, we report a comprehensive, quantitative, and time-resolved analysis using high-resolution mass spectrometry of phospho-proteome and proteome changes in response to osmotic stress in yeast.
NMR spectroscopy and kinetic studies of the quadruplex forming RNA r(UGGAGGU)
Joshua M. Lipay and Mihaela-Rita Mihailescu,
Mol. BioSyst., 2009, 5, 1347
DOI: 10.1039/b911555b Enhanced HTML article available
On the kinetics of a dimeric RNA quadruplex structure containing A:(G:G:G:G):A hexads and G:G:G:G tetrads.
Characterization and development of novel small-molecules inhibiting GSK3 and activating Wnt signaling
Hanbing Zhong, Haixia Zou, Mikhail V. Semenov, Deborah Moshinsky, Xi He, Haigen Huang, Song Li, Junmin Quan, Zhen Yang and Shuo Lin,
Mol. BioSyst., 2009, 5, 1356
DOI: 10.1039/b905752h Enhanced HTML article available
The molecular structure of GSK3 inhibitor 3F8 and its effect on zebrafish embryos.
Evaluation of specific delivery of chimeric phi29 pRNA/siRNA nanoparticles to multiple tumor cells
Li Li, Jing Liu, Zhijuan Diao, Dan Shu, Peixuan Guo and Guanxin Shen,
Mol. BioSyst., 2009, 5, 1361
DOI: 10.1039/b903428e Enhanced HTML article available
In this study, several tumor cell lines were used to evaluate the previously reported pRNA nanotechnology for specific siRNA delivery and for the silencing of targeted genes.
Additions and corrections
Mol. BioSyst., 2009, 5, 1369
DOI: 10.1039/b920315j
Back cover
Mol. BioSyst., 2009, 5, 1371
DOI: 10.1039/b920316h
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