_tcm18-15276.gif )
Latest News
Issue 8 2008 Chemical Biology now published
21 July 2008
Drawing together coverage from all RSC publications, providing an overview of the latest developments in chemical biology
Latest issue of Molecular BioSystems now published!
16 July 2008
For chemical biology, systems biology, -omics and more see the latest issue of our exciting interdisciplinary journal.
4.12 is new Impact Factor for Molecular BioSystems
20 June 2008
New impact factor for Molecular BioSystems is 4.12
Contents list for Molecular BioSystems, issue 8, 2008
Front cover
Mol. BioSyst., 2008, 4, 781
DOI: 10.1039/b811123p
Contents and Chemical Biology
Mol. BioSyst., 2008, 4, 783
DOI: 10.1039/b811124n
Highlights
How chromatin remodelling allows shuffling of immunoglobulin heavy chain genes
Adam J. Bowen and Anne E. Corcoran,
Mol. BioSyst., 2008, 4, 790
DOI: 10.1039/b719771n
Enhanced HTML article available
This review explores the processes implicated in the shuffling of immunoglobulin heavy chain locus genes, including non-coding RNA transcription, histone modifications, transcription factors, nuclear relocation and locus contraction.
Regulation of stress hormones jasmonates and ethylene by MAPK pathways in plants
Alois Schweighofer and Irute Meskiene,
Mol. BioSyst., 2008, 4, 799
DOI: 10.1039/b718578m Enhanced HTML article available
Jasmonates (JAs) and ethylene (ET) are plant stress hormones produced upon abiotic/biotic stress. Here, we highlight recent findings on protein phosphorylation cascades regulating their induction in plants.
Microbial cholesterol oxidases: bioconversion enzymes or signal proteins?
Jesús F. Aparicio and Juan F. Martín,
Mol. BioSyst., 2008, 4, 804
DOI: 10.1039/b717500k Enhanced HTML article available
The recent discovery of cholesterol oxidases implicated in polyene antifungal biosynthesis expands the vast array of properties and biological roles of these fascinating enzymes.
Urinary proteomics: towards biomarker discovery, diagnostics and prognostics
Visith Thongboonkerd,
Mol. BioSyst., 2008, 4, 810
DOI: 10.1039/b802534g Enhanced HTML article available
This article highlights and updates recent progress in the urinary proteomics field, which is moving towards biomarker discovery, diagnostics and prognostics. The concept of biomarker discovery is discussed and examples of successful clinical applications of urinary proteomics are given.
Review Articles
Mass spectrometric analysis of cross-linking sites for the structure of proteins and protein complexes
Young Jin Lee,
Mol. BioSyst., 2008, 4, 816
DOI: 10.1039/b801810c Enhanced HTML article available
Chemical cross-linking of intact proteins or protein complexes followed by mass spectrometric analysis of cross-linked sites is rapidly emerging as a low resolution alternative technology that will supplement current X-ray or NMR based structural proteomics. We introduce this technology with focus on the recent advances.
Stress-related and spontaneous stage differentiation of Toxoplasma gondii
Marialice da Fonseca Ferreira da Silva, Helene S. Barbosa, Uwe Groß and Carsten G. K. Lüder,
Mol. BioSyst., 2008, 4, 824
DOI: 10.1039/b800520f Enhanced HTML article available
Developmental differentiation of the protozoan parasite Toxoplasma gondii is critical for transmission between hosts and for the pathogenesis of human toxoplasmosis. We discuss concepts and recent advances which further our knowledge of the underlying mechanisms.
Cadherins in development and cancer
Marc P. Stemmler,
Mol. BioSyst., 2008, 4, 835
DOI: 10.1039/b719215k Enhanced HTML article available
The importance of cadherin-mediated cell adhesion during embryogenesis and the inappropriate switching among family members during tumour progression is summarized with a focus on E- and N-cadherin.
Communication
Binding of a dinuclear ruthenium(II) complex to the TAR region of the HIV-AIDS viral RNA
Damian P. Buck, Caitriona B. Spillane, J. Grant Collins and F. Richard Keene,
Mol. BioSyst., 2008, 4, 851
DOI: 10.1039/b803216e Enhanced HTML article available
Molecular modelling has identified a new RNA conformational feature created by the insertion of bulge residues into duplex regions that may act as a recognition site for small molecule binding, in particular for inert dinuclear ruthenium complexes.
Papers
Metabonomic study on ageing: NMR-based investigation into rat urinary metabolites and the effect of the total flavone of Epimedium
Bin Wu, Shikai Yan, Zhongying Lin, Qi Wang, Yun Yang, Genjin Yang, Ziyin Shen and Weidong Zhang,
Mol. BioSyst., 2008, 4, 855
DOI: 10.1039/b800923f Enhanced HTML article available
Administration of the total flavone of Epimedium can markedly influence the ageing process and shows anti-ageing effects in rats.
Characterization of a randomized FRET library for protease specificity determination
Jonathan F. Fretwell, Shams M. K. Ismail, Jeffrey M. Cummings and Thomas L. Selby,
Mol. BioSyst., 2008, 4, 862
DOI: 10.1039/b709290c Enhanced HTML article available
We describe the construction and characterization of a FRET protease library using a randomized DNA region between two donor/acceptor proteins for use in both in vivo and in vitro applications.
Back cover
Mol. BioSyst., 2008, 4, 871
DOI: 10.1039/b811125c
RSS feed