Phishing warning 01-May-2024
We are aware of phishing emails targeting speakers of events whose names appear on our events pages. If you are unsure if an email regarding event registration or accommodation has come from us please contact us and do not provide any credit card details or personal information.

Sustainability at AstraZeneca: Use of earth-abundant metal catalysis in Chemical Development

29 October 2024 14:00-15:00, United Kingdom


Introduction
Catalysis is fundamental to the development of sustainable processes in chemical
development, allowing innovative, efficient routes to API molecules that are increasing in
complexity. However, a majority of the catalytic reactions that we develop use platinum group metal
(PGM) catalysts: currently 85% of our routes in late-stage development at AstraZeneca use a
precious metal catalyst. There is a significant environmental footprint associated with the extraction
and isolation of these scarce metals as well as uncertainty in supply.

Replacing these catalysts with those derived from earth-abundant base metals such as Fe, Ni, Cu
would significantly reduce the environmental impact of our processes along with other benefits in
terms of cost and toxicity. High-throughput experimentation has been utilised to investigate and
optimise a range of earth-abundant metal catalysed reactions in the current AstraZeneca portfolio,
including successful examples for nickel-catalysed borylation and Suzuki reactions on complex
molecules in late-stage development. These have been demonstrated to provide significant cost and
sustainability savings to the projects, aligning with AstraZeneca's carbon zero ambition.
Speakers
Venue

United Kingdom

Organised by
Alan Steven
Contact information
Search
 
 
Showing all upcoming events
Start Date
End Date
Location
Subject area
Event type

Advertisement
Spotlight


E-mail Enquiry
*
*
*
*