On the occasion of the 10th anniversary of Organic Chemistry Frontiers, we award Organic Chemistry Frontiers Outstanding Paper Awards 2014-2023. The prizes recognise the contributions of all authors and celebrate these exceptional publications.
The following ten papers were selected by the journal's Editorial and Advisory Board members based on the science presented and a variety of metrics, including article downloads, Altmetric score, and citations. Congratulations to all the winners!
Chiral N,N′-dioxide ligands: synthesis, coordination chemistry and asymmetric catalysis
Xiaohua Liu, Lili Lin and Xiaoming Feng*
Org. Chem. Front., 2014, 1, 298-302
In this tutorial account, conformationally flexible C2-symmetric N,N′-dioxide ligands were coordinated with several metal ions to form useful chiral complex catalysts.
In this review, recent advancements in the condensation of alcohols with pronucleophiles by the Mitsunobu reaction were described.
Transition metal-catalyzed C–H bond functionalizations by the use of diverse directing groups
Zhengkai Chen, Binjie Wang, Jitan Zhang, Wenlong Yu, Zhanxiang Liu* and Yuhong Zhang*
Org. Chem. Front., 2015,2, 1107-1295
In this review, a summary of transition metal-catalyzed C–H activation by utilizing the functionalities as directing groups was presented.
A concise total synthesis of sespenine, a structurally unusual indole terpenoid from Streptomyces
Yu Sun, Zhanchao Meng, Pengxi Chen, Deliang Zhang, Martin Baunach, Christian Hertweckb and Ang Li*
Org. Chem. Front., 2016, 3, 368-374
In this article, a ten-step (the longest linear sequence) total synthesis of sespenine was accomplished.
Gui-Yuan Dou, Yang-Ye Jiang, Kun Xu and Cheng-Chu Zeng*
Org. Chem. Front., 2019, 6, 2392-2397
In this article, an electrochemical methodology for the Minisci-type trifluoromethylation of electron-deficient heterocycles mediated by cheap and easily available bromide ions has been developed.
Shangze Wu, Jonas Žurauskas, Michał Domański, Patrick S. Hitzfeld, Valeria Butera, Daniel J. Scott, Julia Rehbein, Ajeet Kumar, Erling Thyrhaug, Jürgen Hauer and Joshua P. Barham*
Org. Chem. Front., 2021, 8, 1132-1142
In this article, triarylamines were demonstrated as novel, tunable electroactivated photocatalysts that used dispersion precomplexation to harness the full potential of the visible photon (>4.0 V vs. SCE) in anti-Kasha photo(electro)chemical super-oxidations of arenes.
One-step synthesis of polycyclic thianthrenes from unfunctionalized aromatics by thia-APEX reactions
Kou P. Kawahara, Hideto Ito* and Kenichiro Itami*
Org. Chem. Front., 2023, 10, 1880-1889
In this article, thia-APEX reactions affording π-extended thianthrene derivatives from unfunctionalized aromatics were described.
New advances in chiral nanographene chemistry
Hannah V. Anderson, Nicolai D. Gois and Wesley A. Chalifoux*
Org. Chem. Front., 2023, 10, 4167-4197
This review highlighted several recent and lesser-reviewed works related to the preparation of chiral nanographenes, specifically focusing on structures prepared by non-Scholl methods.
Xuejing Peng, Jingxian Huang, Guan-Yu Han and Xing-Zhong Shu*
Org. Chem. Front., 2024, 11, 94-99
In this article, the authors reported a dynamic kinetic cross-electrophile coupling reaction of benzylic alcohols with alkenyl triflates. The reaction enables the replacement of the alcohol group with an alkenyl functionality, yielding versatile benzyl-substituted cyclic alkenes.
Pulsed electrolysis: enhancing primary benzylic C(sp3)–H nucleophilic fluorination
Alexander P. Atkins, Atul K. Chaturvedi, Joseph A. Tate and Alastair J. J. Lennox*
Org. Chem. Front., 2024, 11, 802-808
In this article, pulsed electrolysis waveforms benefit primary benzylic cation generation and fluorination.
Read the full collection of Organic Chemistry Frontiers Oustanding papers 2014 - 2023