Protein-glutamine gamma-glutamyltransferase activity
Definition: Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links.
ID: GO:0003810
Synonyms:
Articles referencing this term
Jo Tominaga, Yoshinori Kemori, Yusuke Tanaka, Tatsuo Maruyama, Noriho Kamiya and Masahiro Goto, Chem. Commun., 2007
, 401
DOI: 10.1039/b613793h
Hans G. Börner and Helmut Schlaad, Soft Matter, 2007
, 3
, 394
DOI: 10.1039/b615985k
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