# Electronic Supplementary Material (ESI) for RSC Advances.
# This journal is © The Royal Society of Chemistry 2015

####################################################################### 
# 
# This file contains crystal structure data downloaded from the 
# Cambridge Structural Database (CSD) hosted by the Cambridge 
# Crystallographic Data Centre (CCDC).
# 
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# guidelines are available at http://www.ccdc.cam.ac.uk/access/V1 
# 
# Audit and citation data items may have been added by the CCDC. 
# Please retain this information to preserve the provenance of 
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data_red
_database_code_depnum_ccdc_archive 'CCDC 1057094'
_audit_update_record             
;
2015-03-31 deposited with the CCDC.
2015-04-15 downloaded from the CCDC.
;
_audit_creation_date             2014-08-21
_audit_creation_method           
;
Olex2 1.2
(compiled 2014.07.22 svn.r2960 for OlexSys, GUI svn.r4862)
;
_shelxl_version_number           2014-1
_chemical_name_common            ?
_chemical_name_systematic        
;
 ?
;
_chemical_formula_moiety         '0.25(C23 H15 Cl F N O2)'
_chemical_formula_sum            'C5.75 H3.75 Cl0.25 F0.25 N0.25 O0.50'
_chemical_formula_weight         97.95
_chemical_melting_point          ?
loop_
_atom_type_symbol
_atom_type_description
_atom_type_scat_dispersion_real
_atom_type_scat_dispersion_imag
_atom_type_scat_source
C C 0.0033 0.0016 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
H H 0.0000 0.0000 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
Cl Cl 0.1484 0.1585 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
F F 0.0171 0.0103 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
N N 0.0061 0.0033 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
O O 0.0106 0.0060 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'

_shelx_space_group_comment       
;
The symmetry employed for this shelxl refinement is uniquely defined
by the following loop, which should always be used as a source of
symmetry information in preference to the above space-group names.
They are only intended as comments.
;
_space_group_crystal_system      monoclinic
_space_group_IT_number           15
_space_group_name_H-M_alt        'C 1 2/c 1'
_space_group_name_Hall           '-C 2yc'
loop_
_space_group_symop_operation_xyz
'x, y, z'
'-x, y, -z+1/2'
'x+1/2, y+1/2, z'
'-x+1/2, y+1/2, -z+1/2'
'-x, -y, -z'
'x, -y, z-1/2'
'-x+1/2, -y+1/2, -z'
'x+1/2, -y+1/2, z-1/2'

_cell_length_a                   27.292(5)
_cell_length_b                   10.0001(19)
_cell_length_c                   15.408(3)
_cell_angle_alpha                90
_cell_angle_beta                 116.511(10)
_cell_angle_gamma                90
_cell_volume                     3763.0(12)
_cell_formula_units_Z            32
_cell_measurement_reflns_used    4280
_cell_measurement_temperature    298(2)
_cell_measurement_theta_max      ?
_cell_measurement_theta_min      ?
_shelx_estimated_absorpt_T_max   ?
_shelx_estimated_absorpt_T_min   ?
_exptl_absorpt_coefficient_mu    0.231
_exptl_absorpt_correction_T_max  0.7456
_exptl_absorpt_correction_T_min  0.6866
_exptl_absorpt_correction_type   multi-scan
_exptl_absorpt_process_details   
;
SADABS-2012/1 (Bruker,2012) was used for absorption correction.
wR2(int) was 0.1062 before and 0.0696 after correction.
The Ratio of minimum to maximum transmission is 0.9209.
The λ/2 correction factor is 0.0015.
;
_exptl_crystal_colour            'clear reddish colourless'
_exptl_crystal_colour_lustre     clear
_exptl_crystal_colour_modifier   reddish
_exptl_crystal_colour_primary    colourless
_exptl_crystal_density_diffrn    1.383
_exptl_crystal_density_meas      .
_exptl_crystal_density_method    ?
_exptl_crystal_description       block
_exptl_crystal_F_000             1616
_exptl_crystal_size_max          0.34
_exptl_crystal_size_mid          0.29
_exptl_crystal_size_min          0.25
_exptl_special_details           
;
 ?
;
_exptl_transmission_factor_max   ?
_exptl_transmission_factor_min   ?
_diffrn_reflns_av_R_equivalents  0.0668
_diffrn_reflns_av_unetI/netI     0.0636
_diffrn_reflns_Laue_measured_fraction_full 0.996
_diffrn_reflns_Laue_measured_fraction_max 0.981
_diffrn_reflns_limit_h_max       35
_diffrn_reflns_limit_h_min       -26
_diffrn_reflns_limit_k_max       12
_diffrn_reflns_limit_k_min       -12
_diffrn_reflns_limit_l_max       19
_diffrn_reflns_limit_l_min       -19
_diffrn_reflns_number            22200
_diffrn_reflns_point_group_measured_fraction_full 0.996
_diffrn_reflns_point_group_measured_fraction_max 0.981
_diffrn_reflns_theta_full        25.242
_diffrn_reflns_theta_max         27.472
_diffrn_reflns_theta_min         1.668
_diffrn_ambient_temperature      298
_diffrn_detector_area_resol_mean ?
_diffrn_measured_fraction_theta_full 0.996
_diffrn_measured_fraction_theta_max 0.981
_diffrn_measurement_device_type  'Bruker APEX-II CCD'
_diffrn_measurement_method       'φ and ω scans'
_diffrn_radiation_monochromator  graphite
_diffrn_radiation_type           MoK\a
_diffrn_radiation_wavelength     0.71073
_diffrn_source                   ?
_diffrn_standards_number         0
_reflns_Friedel_coverage         0.000
_reflns_Friedel_fraction_full    .
_reflns_Friedel_fraction_max     .
_reflns_number_gt                2151
_reflns_number_total             4218
_reflns_special_details          
;
 Reflections were merged by SHELXL according to the crystal
 class for the calculation of statistics and refinement.
 
 _reflns_Friedel_fraction is defined as the number of unique
 Friedel pairs measured divided by the number that would be
 possible theoretically, ignoring centric projections and
 systematic absences.
;
_reflns_threshold_expression     'I > 2σ(I)'
_computing_cell_refinement       'SAINT v8.27A (Bruker, 2012)'
_computing_data_collection       ?
_computing_data_reduction        'SAINT v8.27A (Bruker, 2012)'
_computing_molecular_graphics    'Olex2 (Dolomanov et al., 2009)'
_computing_publication_material  'Olex2 (Dolomanov et al., 2009)'
_computing_structure_refinement  'ShelXL (Sheldrick, 2008)'
_computing_structure_solution    ?
_refine_diff_density_max         0.225
_refine_diff_density_min         -0.307
_refine_diff_density_rms         0.042
_refine_ls_extinction_coef       0.0011(3)
_refine_ls_extinction_expression Fc^*^=kFc[1+0.001xFc²λ³/sin(2θ)]^-1/4^
_refine_ls_extinction_method     SHELXL
_refine_ls_goodness_of_fit_ref   1.001
_refine_ls_hydrogen_treatment    constr
_refine_ls_matrix_type           full
_refine_ls_number_parameters     255
_refine_ls_number_reflns         4218
_refine_ls_number_restraints     0
_refine_ls_R_factor_all          0.1134
_refine_ls_R_factor_gt           0.0457
_refine_ls_restrained_S_all      1.001
_refine_ls_shift/su_max          0.001
_refine_ls_shift/su_mean         0.000
_refine_ls_structure_factor_coef Fsqd
_refine_ls_weighting_details     
'w=1/[σ²(Fo²)+(0.0678P)²] where P=(Fo²+2Fc²)/3'
_refine_ls_weighting_scheme      calc
_refine_ls_wR_factor_gt          0.1183
_refine_ls_wR_factor_ref         0.1427
_refine_special_details          
;
 ?
;
_olex2_refinement_description    
;
1. Fixed Uiso
 At 1.2 times of:
  All C(H) groups
 At 1.5 times of:
  All C(H,H,H) groups
2.a Aromatic/amide H refined with riding coordinates:
 C2(H2), C3(H3), C8(H8), C11(H11), C13(H13), C14(H14), C21(H21), C22(H22),
 C23(H23), C24(H24), C25(H25), C26(H26)
2.b Idealised Me refined as rotating group:
 C17(H17A,H17B,H17C)
;
_atom_sites_solution_hydrogens   geom
_atom_sites_solution_primary     ?
_atom_sites_solution_secondary   ?
loop_
_atom_site_label
_atom_site_type_symbol
_atom_site_fract_x
_atom_site_fract_y
_atom_site_fract_z
_atom_site_U_iso_or_equiv
_atom_site_adp_type
_atom_site_occupancy
_atom_site_site_symmetry_order
_atom_site_calc_flag
_atom_site_refinement_flags_posn
_atom_site_refinement_flags_adp
_atom_site_refinement_flags_occupancy
_atom_site_disorder_assembly
_atom_site_disorder_group
Cl1 Cl 0.69964(3) 0.29417(7) 0.07762(5) 0.0841(3) Uani 1 1 d . . . . .
F1 F 1.08909(5) 0.34720(14) 0.36167(10) 0.0800(4) Uani 1 1 d . . . . .
C1 C 0.73614(9) 0.4449(2) 0.10980(15) 0.0593(6) Uani 1 1 d . . . . .
C2 C 0.78398(9) 0.4576(2) 0.10072(15) 0.0583(6) Uani 1 1 d . . . . .
H2 H 0.7971 0.3865 0.0782 0.070 Uiso 1 1 calc R . . . .
C3 C 0.81212(9) 0.5777(2) 0.12567(15) 0.0535(6) Uani 1 1 d . . . . .
H3 H 0.8443 0.5870 0.1194 0.064 Uiso 1 1 calc R . . . .
C4 C 0.79331(8) 0.6847(2) 0.15984(14) 0.0493(5) Uani 1 1 d . . . . .
C5 C 0.82391(9) 0.8138(2) 0.18562(14) 0.0522(6) Uani 1 1 d . . . . .
C6 C 0.88115(9) 0.8193(2) 0.24390(15) 0.0495(5) Uani 1 1 d . . . . .
C7 C 0.91603(9) 0.7004(2) 0.29292(15) 0.0511(6) Uani 1 1 d . . . . .
C8 C 0.89622(8) 0.60317(19) 0.34215(13) 0.0447(5) Uani 1 1 d . . . . .
H8 H 0.8633 0.6240 0.3434 0.054 Uiso 1 1 calc R . . . .
C9 C 0.92012(7) 0.48815(19) 0.38526(13) 0.0411(5) Uani 1 1 d . . . . .
C10 C 0.96795(8) 0.40955(18) 0.39596(13) 0.0405(5) Uani 1 1 d . . . . .
C11 C 1.00949(8) 0.4288(2) 0.36798(14) 0.0479(5) Uani 1 1 d . . . . .
H11 H 1.0112 0.5063 0.3360 0.058 Uiso 1 1 calc R . . . .
C12 C 1.04789(9) 0.3290(2) 0.38941(16) 0.0580(6) Uani 1 1 d . . . . .
C13 C 1.04796(10) 0.2141(2) 0.43722(19) 0.0679(7) Uani 1 1 d . . . . .
H13 H 1.0748 0.1494 0.4495 0.082 Uiso 1 1 calc R . . . .
C14 C 1.00748(10) 0.1948(2) 0.46737(18) 0.0646(7) Uani 1 1 d . . . . .
H14 H 1.0069 0.1177 0.5007 0.078 Uiso 1 1 calc R . . . .
C15 C 0.96785(9) 0.2932(2) 0.44659(15) 0.0488(5) Uani 1 1 d . . . . .
N16 N 0.92359(7) 0.29396(17) 0.46994(13) 0.0538(5) Uani 1 1 d . . . . .
C17 C 0.91385(10) 0.1954(2) 0.52992(19) 0.0775(8) Uani 1 1 d . . . . .
H17A H 0.9100 0.1085 0.5011 0.116 Uiso 1 1 calc GR . . . .
H17B H 0.8809 0.2178 0.5347 0.116 Uiso 1 1 calc GR . . . .
H17C H 0.9442 0.1949 0.5935 0.116 Uiso 1 1 calc GR . . . .
C18 C 0.89355(9) 0.4087(2) 0.43655(15) 0.0486(5) Uani 1 1 d . . . . .
O19 O 0.85302(6) 0.43955(16) 0.44673(11) 0.0670(5) Uani 1 1 d . . . . .
O20 O 0.96175(7) 0.69191(16) 0.29736(14) 0.0810(6) Uani 1 1 d . . . . .
C21 C 0.90816(10) 0.9422(2) 0.25919(17) 0.0662(6) Uani 1 1 d . . . . .
H21 H 0.9460 0.9454 0.2957 0.079 Uiso 1 1 calc R . . . .
C22 C 0.87957(13) 1.0587(3) 0.2210(2) 0.0803(8) Uani 1 1 d . . . . .
H22 H 0.8979 1.1401 0.2326 0.096 Uiso 1 1 calc R . . . .
C23 C 0.82330(14) 1.0534(3) 0.1651(2) 0.0865(9) Uani 1 1 d . . . . .
H23 H 0.8038 1.1317 0.1392 0.104 Uiso 1 1 calc R . . . .
C24 C 0.79600(11) 0.9327(3) 0.14780(17) 0.0708(7) Uani 1 1 d . . . . .
H24 H 0.7583 0.9308 0.1101 0.085 Uiso 1 1 calc R . . . .
C25 C 0.74444(9) 0.6684(3) 0.16691(16) 0.0640(6) Uani 1 1 d . . . . .
H25 H 0.7307 0.7396 0.1883 0.077 Uiso 1 1 calc R . . . .
C26 C 0.71599(9) 0.5494(3) 0.14287(16) 0.0663(7) Uani 1 1 d . . . . .
H26 H 0.6837 0.5396 0.1489 0.080 Uiso 1 1 calc R . . . .


_geom_special_details            
;
 All esds (except the esd in the dihedral angle between two l.s. planes)
 are estimated using the full covariance matrix.  The cell esds are taken
 into account individually in the estimation of esds in distances, angles
 and torsion angles; correlations between esds in cell parameters are only
 used when they are defined by crystal symmetry.  An approximate (isotropic)
 treatment of cell esds is used for estimating esds involving l.s. planes.
;
loop_
_geom_bond_atom_site_label_1
_geom_bond_atom_site_label_2
_geom_bond_distance
_geom_bond_site_symmetry_2
_geom_bond_publ_flag
Cl1 C1 1.752(2) . ?
F1 C12 1.382(2) . ?
C1 C2 1.380(3) . ?
C1 C26 1.379(3) . ?
C2 H2 0.9300 . ?
C2 C3 1.385(3) . ?
C3 H3 0.9300 . ?
C3 C4 1.388(3) . ?
C4 C5 1.492(3) . ?
C4 C25 1.395(3) . ?
C5 C6 1.413(3) . ?
C5 C24 1.392(3) . ?
C6 C7 1.499(3) . ?
C6 C21 1.398(3) . ?
C7 C8 1.476(3) . ?
C7 O20 1.222(2) . ?
C8 H8 0.9300 . ?
C8 C9 1.343(3) . ?
C9 C10 1.469(3) . ?
C9 C18 1.514(3) . ?
C10 C11 1.394(3) . ?
C10 C15 1.401(3) . ?
C11 H11 0.9300 . ?
C11 C12 1.376(3) . ?
C12 C13 1.365(3) . ?
C13 H13 0.9300 . ?
C13 C14 1.390(3) . ?
C14 H14 0.9300 . ?
C14 C15 1.390(3) . ?
C15 N16 1.406(3) . ?
N16 C17 1.454(3) . ?
N16 C18 1.370(3) . ?
C17 H17A 0.9600 . ?
C17 H17B 0.9600 . ?
C17 H17C 0.9600 . ?
C18 O19 1.224(2) . ?
C21 H21 0.9300 . ?
C21 C22 1.379(3) . ?
C22 H22 0.9300 . ?
C22 C23 1.386(4) . ?
C23 H23 0.9300 . ?
C23 C24 1.381(4) . ?
C24 H24 0.9300 . ?
C25 H25 0.9300 . ?
C25 C26 1.379(3) . ?
C26 H26 0.9300 . ?

loop_
_geom_angle_atom_site_label_1
_geom_angle_atom_site_label_2
_geom_angle_atom_site_label_3
_geom_angle
_geom_angle_site_symmetry_1
_geom_angle_site_symmetry_3
_geom_angle_publ_flag
C2 C1 Cl1 119.61(19) . . ?
C26 C1 Cl1 119.07(17) . . ?
C26 C1 C2 121.3(2) . . ?
C1 C2 H2 120.5 . . ?
C1 C2 C3 118.9(2) . . ?
C3 C2 H2 120.5 . . ?
C2 C3 H3 119.3 . . ?
C2 C3 C4 121.39(19) . . ?
C4 C3 H3 119.3 . . ?
C3 C4 C5 120.66(18) . . ?
C3 C4 C25 117.9(2) . . ?
C25 C4 C5 121.43(19) . . ?
C6 C5 C4 122.10(17) . . ?
C24 C5 C4 119.4(2) . . ?
C24 C5 C6 118.4(2) . . ?
C5 C6 C7 124.26(19) . . ?
C21 C6 C5 119.41(19) . . ?
C21 C6 C7 116.3(2) . . ?
C8 C7 C6 119.02(18) . . ?
O20 C7 C6 119.12(17) . . ?
O20 C7 C8 121.62(18) . . ?
C7 C8 H8 116.2 . . ?
C9 C8 C7 127.59(17) . . ?
C9 C8 H8 116.2 . . ?
C8 C9 C10 136.48(17) . . ?
C8 C9 C18 117.87(17) . . ?
C10 C9 C18 105.63(17) . . ?
C11 C10 C9 134.10(18) . . ?
C11 C10 C15 119.38(18) . . ?
C15 C10 C9 106.52(17) . . ?
C10 C11 H11 121.2 . . ?
C12 C11 C10 117.6(2) . . ?
C12 C11 H11 121.2 . . ?
C11 C12 F1 117.9(2) . . ?
C13 C12 F1 118.2(2) . . ?
C13 C12 C11 123.9(2) . . ?
C12 C13 H13 120.4 . . ?
C12 C13 C14 119.2(2) . . ?
C14 C13 H13 120.4 . . ?
C13 C14 H14 120.7 . . ?
C13 C14 C15 118.5(2) . . ?
C15 C14 H14 120.7 . . ?
C10 C15 N16 110.69(17) . . ?
C14 C15 C10 121.4(2) . . ?
C14 C15 N16 127.9(2) . . ?
C15 N16 C17 125.50(18) . . ?
C18 N16 C15 110.29(16) . . ?
C18 N16 C17 123.89(18) . . ?
N16 C17 H17A 109.5 . . ?
N16 C17 H17B 109.5 . . ?
N16 C17 H17C 109.5 . . ?
H17A C17 H17B 109.5 . . ?
H17A C17 H17C 109.5 . . ?
H17B C17 H17C 109.5 . . ?
N16 C18 C9 106.83(17) . . ?
O19 C18 C9 127.27(19) . . ?
O19 C18 N16 125.90(18) . . ?
C6 C21 H21 119.5 . . ?
C22 C21 C6 121.0(2) . . ?
C22 C21 H21 119.5 . . ?
C21 C22 H22 120.3 . . ?
C21 C22 C23 119.4(2) . . ?
C23 C22 H22 120.3 . . ?
C22 C23 H23 119.8 . . ?
C24 C23 C22 120.4(2) . . ?
C24 C23 H23 119.8 . . ?
C5 C24 H24 119.4 . . ?
C23 C24 C5 121.2(2) . . ?
C23 C24 H24 119.4 . . ?
C4 C25 H25 119.2 . . ?
C26 C25 C4 121.5(2) . . ?
C26 C25 H25 119.2 . . ?
C1 C26 H26 120.5 . . ?
C25 C26 C1 118.9(2) . . ?
C25 C26 H26 120.5 . . ?

loop_
_geom_torsion_atom_site_label_1
_geom_torsion_atom_site_label_2
_geom_torsion_atom_site_label_3
_geom_torsion_atom_site_label_4
_geom_torsion
_geom_torsion_site_symmetry_1
_geom_torsion_site_symmetry_2
_geom_torsion_site_symmetry_3
_geom_torsion_site_symmetry_4
_geom_torsion_publ_flag
Cl1 C1 C2 C3 179.46(16) . . . . ?
Cl1 C1 C26 C25 -179.15(17) . . . . ?
F1 C12 C13 C14 178.83(19) . . . . ?
C1 C2 C3 C4 0.3(3) . . . . ?
C2 C1 C26 C25 0.2(3) . . . . ?
C2 C3 C4 C5 -179.51(19) . . . . ?
C2 C3 C4 C25 -1.0(3) . . . . ?
C3 C4 C5 C6 -47.6(3) . . . . ?
C3 C4 C5 C24 129.4(2) . . . . ?
C3 C4 C25 C26 1.3(3) . . . . ?
C4 C5 C6 C7 -5.8(3) . . . . ?
C4 C5 C6 C21 174.93(17) . . . . ?
C4 C5 C24 C23 -176.1(2) . . . . ?
C4 C25 C26 C1 -0.9(3) . . . . ?
C5 C4 C25 C26 179.8(2) . . . . ?
C5 C6 C7 C8 -43.2(3) . . . . ?
C5 C6 C7 O20 142.2(2) . . . . ?
C5 C6 C21 C22 2.2(3) . . . . ?
C6 C5 C24 C23 1.0(3) . . . . ?
C6 C7 C8 C9 176.27(19) . . . . ?
C6 C21 C22 C23 -1.2(4) . . . . ?
C7 C6 C21 C22 -177.1(2) . . . . ?
C7 C8 C9 C10 -5.5(4) . . . . ?
C7 C8 C9 C18 176.32(18) . . . . ?
C8 C9 C10 C11 3.7(4) . . . . ?
C8 C9 C10 C15 -176.8(2) . . . . ?
C8 C9 C18 N16 177.03(17) . . . . ?
C8 C9 C18 O19 -2.9(3) . . . . ?
C9 C10 C11 C12 -178.59(19) . . . . ?
C9 C10 C15 C14 178.68(19) . . . . ?
C9 C10 C15 N16 -0.9(2) . . . . ?
C10 C9 C18 N16 -1.7(2) . . . . ?
C10 C9 C18 O19 178.42(19) . . . . ?
C10 C11 C12 F1 179.83(16) . . . . ?
C10 C11 C12 C13 -0.9(3) . . . . ?
C10 C15 N16 C17 -173.9(2) . . . . ?
C10 C15 N16 C18 -0.2(2) . . . . ?
C11 C10 C15 C14 -1.7(3) . . . . ?
C11 C10 C15 N16 178.70(16) . . . . ?
C11 C12 C13 C14 -0.4(3) . . . . ?
C12 C13 C14 C15 0.7(3) . . . . ?
C13 C14 C15 C10 0.4(3) . . . . ?
C13 C14 C15 N16 179.87(19) . . . . ?
C14 C15 N16 C17 6.5(3) . . . . ?
C14 C15 N16 C18 -179.8(2) . . . . ?
C15 C10 C11 C12 1.9(3) . . . . ?
C15 N16 C18 C9 1.2(2) . . . . ?
C15 N16 C18 O19 -178.92(19) . . . . ?
C17 N16 C18 C9 175.02(19) . . . . ?
C17 N16 C18 O19 -5.1(3) . . . . ?
C18 C9 C10 C11 -178.0(2) . . . . ?
C18 C9 C10 C15 1.56(19) . . . . ?
O20 C7 C8 C9 -9.3(3) . . . . ?
C21 C6 C7 C8 136.0(2) . . . . ?
C21 C6 C7 O20 -38.6(3) . . . . ?
C21 C22 C23 C24 0.0(4) . . . . ?
C22 C23 C24 C5 0.1(4) . . . . ?
C24 C5 C6 C7 177.16(18) . . . . ?
C24 C5 C6 C21 -2.1(3) . . . . ?
C25 C4 C5 C6 134.0(2) . . . . ?
C25 C4 C5 C24 -49.1(3) . . . . ?
C26 C1 C2 C3 0.1(3) . . . . ?

_olex2_submission_special_instructions 'No special instructions were received'
