Additions and corrections

A novel isocyanide based three component reaction

Oliver T. Kern and William B. Motherwell

Chem. Commun., 2003, 2988-2989 (DOI: 10.1039/b310962c) Amendment published 1st March 2005

Scheme 1

The authors recently reported a novel multicomponent reaction featuring an isocyanide, an epoxide and a carboxylic acid. As a consequence of further experiments designed to extend the scope of this reaction,¹ the authors have now discovered that the structural assignments of the products in their original communication are incorrect. The correct structures for the overall reactions are shown in Scheme 1 and arise as a consequence of S_N1-like ring opening of the epoxide followed by hydride migration and subsequent Passerini-type reaction of the resulting carbonyl compound.

1. S. T. Hilton, W. B. Motherwell, T. D. Sheppard and R. Waller, unpublished observations.

The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.

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