File Name : figure s3.pdf

Caption : figure s3. ato inhibits pscs activation and alleviates the tumor-promoting function. a. after treated with ato of different concentration, the proteins expression was detected by western blot and quantified by image j. b. the wound healing percentage was utilized to quantify the migration ability of panc-1 and mia paca-2. all the results were repeated for 3 times. *, p < 0.05; **, p < 0.01.

File Name : figure s4.pdf

Caption : figure s4. quantification results of figure 5. all the protein expression in figure 5 were repeated for 3 times and the data were represented as mean and standard deviation (sd). *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001.

File Name : figure s5.pdf

Caption : figure s5. the synthesis and characterization of mal-peg-pdlla. a. the reaction pathway of of mal-peg-pdlla. b. 1h nmr spectrum of mal-peg-pdlla in cdcl3 at 25 ℃. characteristic peaks of maleimide group, peg and pdlla were located at about 6.7 ppm, 3.6 ppm and 5.2 ppm (ch), 1.6 ppm (ch3), respectively. c. the stability of scab-ato-nps. the diameter of scab-ato-nps varied between 160 and 190nm for 48 hours.

File Name : figure s6.pdf

Caption : figure s6. scab-ato-nps inhibited pscs activation. a. the protein expression in figure 6g was quantified by image j. b. the wound healing percentage was utilized to quantify the migration ability of panc-1 and mia paca-2. all the results were repeated for 3 times. *, p < 0.05; **, p < 0.01.***, p < 0.001.

File Name : figure s7.pdf

Caption : figure s7. quantitative analysis of the fluorescence in each organ by image j software. tumors and organs were separated from tumor bearing mice received tail vein injection with rhb-nps and scab-rhb-nps and aggregation and distribution of tumors and organs was recorded. the fluorescence intensity of tumors was significantly higher in mice administered scab-rhb-nps than in rhb-nps (2.54-fold，p < 0.01).

File Name : figure s8.pdf

Caption : figure s8 h&e staining of five organs. morphological changes were not be observed after being treated with ato of different formulations. scale bars, 50μm.

File Name : figure s9.pdf

Caption : figure s9 serum test of balb/c nude mice after treatments of scab-ato-nps. ast, aspartate aminotransferase; alt, alanine aminotransferase; cre, creatinine. the data are presented as the mean (sd) (n = 3)