File Name : fig. s1.tif

Caption : fig. s1. the relative abundance of the top 10 gut microbiota at the phylum level (a, c) and genus level (b, d) in the colitis mice pre-treated and post-treated with l.
paraplantarum lr-1 biofilm and planktonic cells (n=6).

File Name : fig s2.tif

Caption : fig. s2. the differential metabolites in the m vs. c (a), pm vs. c (b), bm vs. c (c), pm vs. m (d), bm vs. m (e), and bm vs. pm (f) group comparisons of the intestinal content of the colitis mice pre-treated with l. paraplantarum lr-1 biofilm and planktonic cells. the d vs. c (g), dp vs. c (h), db vs. c (i), dp vs. c (j), db vs. d (k), and db vs. dp (l) group comparisons of the intestinal content of the colitis mice treated with l. paraplantarum lr-1 biofilm and planktonic cells. the different metabolites between the two groups were selected using
student’s t-test (p<0.05). in the volcano, the red and blue dot represents an up-regulation (fold change>2.0 and p<0.05) and down-regulation (fold change< 0.5 and p<0.05) metabolite, respectively, while the gray dot represents no significant metabolite (|log2 fold change|<1.0 or p>0.05). in addition, label “+” and “-” indicates positive and negative mode, respectively.

File Name : fig s3.tif

Caption : fig. s3. the pca (a), pls-da (b), and oplas-da of the metabolites in the m vs. c (c), pm vs. c (d), bm vs. c i, pm vs. m (f), bm vs. m (g), and bm vs. pm (h) group comparisons during
the preventive evaluation experiment. the pca (i), pls-da (j), and oplas-da of the metabolites in the d vs. c (k), dp vs. c (l), db vs. c (m), dp vs. d (n), db vs. d (o), and db vs. dp
(p) group comparisons during the therapeutic evaluation experiment (n=6). the ellipses represent 95% confidence intervals around the centroid of each data cluster.