Additions and corrections

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Mathematical model of PAR1-mediated activation of human platelets

Leonardo Lenoci , Matthew Duvernay , Shalanda Satchell , Emmanuele DiBenedetto and Heidi E. Hamm

Mol. BioSyst., 2010, 7, 1129–1137 (DOI: 10.1039/10.1039/C0MB00250J ). Amendment published 8th March 2012.

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Five kinetic parameters in ‘Table 1: Symbolic reaction schemes and effective kinetic parameters used in the simulation of a PAR1-stimulated human platelet’ were changed in the model and inadvertently not changed in Table 1:

Reactions governing PKB/Akt activation:

βγ + Akt ↔ Akt*: k₁=2.00 x 10⁶ M^-1s^-1 k_-1=1.00 x 10^-5 s^-1

Reactions governing PLD activity:

PA ↔ DAG: k_-1=2.70 x 10^-2 s^-1

Reactions governing Rap1 activation:

CalDAG-GEF + DAG + Ca²⁺ ↔ CalDAG-GEF*: k₁=2.00 x 10⁹ M^-2s^-1 k_-1=1.50 s^-1

At the end of the second paragraph in Conclusions we expand the sentence: ‘Analogously, we showed how Rap1 attenuated responses in platelets treated with Akt X could be studied by tuning the output of the module that regulates Rap1 activation by Akt.’ by ‘choosing the Akt parameters in Table 1 (figure 4D.)’.

We also have some new supplementary information:

function[par1,gq,plc,pld_activity,g12_13,rho,ca,dag,gi,pi3k,integrin,… new_pkc,new_pld,akt] =switches
par1=true;
gq=true;
plc=true;
pld_activity=true;
g12_13=true;
rho=true;
ca=true;
dag=true;
gi=true;
pi3k=false; % always false
integrin=true;
new_pkc=true;
new_pld=true;
akt=true;
return

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The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.

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