Synopsis
Process Development is the application of chemistry to the scale up of new synthetic processes from the laboratory, through pilot plant to full scale commercial manufacture and into life cycle management. It is an extremely broad discipline, crossing the boundaries between synthetic organic chemistry, process technology and chemical engineering.
The area of Process Development continues to be a challenging and important area for the research into and application of modern synthetic organic chemistry, as well as enabling technologies.
Programme
Wednesday 6 April
11:00 Registration and coffee
12:15 Lunch
13:25 Opening remarks
13:30 Crizotinib(Xalkori ®): route identification, process development and post approval challenges in the commercialisation of a rapidly accelerated precision medicine
Dr Gemma Scotney, Pfizer
14:10 Process intensification via the integration of membranes in(bio)chemical reactions
Dr Dominic Ormerod, Vito
14:50 The science and safety of chemical production with diazonium salts
Dr Matthew Hughes
15:30 Refreshment break
16:10 Recent advances in developing enzymatic processes for chemical production
Dr Alex Tao, EnzymeWorks
16:50 Dave Ager memorial talk - flow chemistry: a new paradigm
Dr Andre De-Vries, DSM
17:30 Closing remarks
17:45 Wine reception
19:00 Dinner for residents in the dining hall
Thursday 7 April
09:00 Adventures in chemistry from the nanomole to the kilomole scale
Dr Ian Davies, Merck
09:40 Micro reactors
Speaker from DSM
10:20 Refreshment break
10:50 Synthetic evolution and chemical innovation: developing an efficient synthesis of the potent JAK2 inhibitor, BMS-911543
Dr Martin Eastgate, BMS
11:30 Strategies for optimisation of continuous flow processes
Dr Richard Bourne, Leeds University
12:10 Lunch
13:10 Crop protection R&D in the agrochemical industry: process research at Dow AgroSciences with case studies
Dr Nick Irvine, Dow
13:50 Cost reduction through process optimisation: the atorvastatin sidechain
Dr Sebastian Kroll, Dr Reddys
14:30 Evolution of an enzymatic process for the manufacture of amoxicillin
Dr Matt John, GlaxoSmithKline
15:10 Refreshment break
15:40 Fine chemical technologies for novel agrochemical ingredients
Dr Rob Bryant, Agranova
16:20 Prize for process chemistry research 2015
17:20 Closing remarks
17:30 Wine reception
19:00 Conference dinner in the dining hall
Friday 8 April
09:00 Synthesis of the nucleoside analogue lagociclovir valactate
Dr Johan Wennerberg, Chemoswed
09:40 Tagrisso™: process development on the critical path
Dr Gwydion Churchill, AstraZeneca
10:20 Refreshment break
10:50 Surfactants in water as a sustainable reaction medium – focus on amidation reactions
Dr Michael Parmentier, Novartis
11:30 AJIPHASE®; novel and practical liquid-phase oligonucleotides and peptides synthesis for large scale manufacturing
Mr Ryotaro Nakaya, Ajinomoto
12:10 Conference close
