Synopsis
This meeting aims to showcase vignettes of modern medicinal chemistry to bring new thinking to the subject, challenge perceptions and encourage scientific interaction between researchers. The short presentation format of the meeting also aims to provide a focussed forum to promote examples of medicinal chemistry excellence.Attendees
This meeting is targeted at academic and industrial scientists engaged in all aspects of the drug discovery process and those interested in broadening their knowledge at the forefront of medicinal chemistry.Programme
09.00 Registration and refreshments
09.50 Opening remarks
09.55 The realisation of activity-directed synthesis Prof Adam Nelson, University of Leeds
10.35 Structure-based design of drug-like macrocycles to probe the role of MTH1 in cancer
Dr Jason Kettle, AstraZeneca
11.15 Refreshments
11.35 Development of novel, selective and irreversible PI3K inhibitors
Mr Samuel Dalton, University of Strathclyde / GlaxoSmithKline
12.00 Discovery of the first cell-active inhibitors of poly(ADP ribose) glycohydrolase (PARG) through high-throughput screening and computational approaches
Dr Kate Smith, Cancer Research UK Manchester Institute
12.25 Discovery of a small molecule that mitigates hearing loss in a model of Usher syndrome III
Dr Chris Lock, Discovery from Charles River
12.50 Lunch
13.50 Discovery of novel TACE inhibitors for topical treatment of psoriasis
Dr Gilles Ouvry, Galderma
14.15 Discovery of CCT251921: A potent, selective and orally bioavailable small molecule modulator of the mediator complex-associated kinases CDK8 and CDK19
Dr Aurélie Mallinger, The Institute of Cancer Research
14.40 Increasing solubility for free
Dr Timothy Ritchie, TJR-Chem
15.20 Refreshments
15.40 Extracting actionable knowledge from large scale in vitro pharmacology data
Dr Al Dossetter, MedChemica
16.05 Receptor kinetics vs CNS exposure: which is more important for a ghrelin inverse agonist?
Dr William McCoull, AstraZeneca
16.30 Chemical probes for epigenetic proteins
Prof Paul Brennan, University of Oxford
17.10 Closing remarks
17.15 Wine reception
Sponsorship
If you are interested in in sponsorship opportunities, please contact conferences@soci.org.
