Deciphering Transition Metal Signaling with Activity-Based Sensing
Christopher J. Chang
University of California, Berkeley, United States
Metals are essential for all forms of life, and the traditional view of this biological inorganic chemistry is that mobile fluxes of redox-innocent metals like sodium, potassium, and calcium are privileged as dynamic signals while redox-active transition metals like copper and iron must be buried and protected as static metabolic cofactors to prevent oxidative stress. We are advancing a new paradigm of transition metal signaling, using copper and iron as primary examples to show a broader metabolism/signaling continuum that can influence neural circuitry and regulate fundamental behaviors. This presentation will focus on our latest efforts to decipher new roles for metals in living systems, enabled by chemical technologies such as activity-based sensing.
Catalytic Methods for Carbon-Fluorine Bond Construction
F. Dean Toste
Department of Chemistry, University of California, Berkeley, CA, USA
This lecture will focus on the catalytic construction of carbon-fluorine bonds. The development of a strategy based on the delivery of cationic fluorinating reagents by means of chiral anion phase transfer catalysis (CAPT) will be discussed. The CAPT method allows for the generation of C-F bonds through direct fluorination of nucleophiles or by fluorocyclization reactions of alkenes. A complimentary approach involving transition-metal catalyzed enantioselective C-F bond constructions will also be introduced. The transition metal-based approach allows for the generation of complexity through the simultaneous formation of C-F and C-C bond.
Christopher J. Chang
University of California, Berkeley, United States
Metals are essential for all forms of life, and the traditional view of this biological inorganic chemistry is that mobile fluxes of redox-innocent metals like sodium, potassium, and calcium are privileged as dynamic signals while redox-active transition metals like copper and iron must be buried and protected as static metabolic cofactors to prevent oxidative stress. We are advancing a new paradigm of transition metal signaling, using copper and iron as primary examples to show a broader metabolism/signaling continuum that can influence neural circuitry and regulate fundamental behaviors. This presentation will focus on our latest efforts to decipher new roles for metals in living systems, enabled by chemical technologies such as activity-based sensing.
Catalytic Methods for Carbon-Fluorine Bond Construction
F. Dean Toste
Department of Chemistry, University of California, Berkeley, CA, USA
This lecture will focus on the catalytic construction of carbon-fluorine bonds. The development of a strategy based on the delivery of cationic fluorinating reagents by means of chiral anion phase transfer catalysis (CAPT) will be discussed. The CAPT method allows for the generation of C-F bonds through direct fluorination of nucleophiles or by fluorocyclization reactions of alkenes. A complimentary approach involving transition-metal catalyzed enantioselective C-F bond constructions will also be introduced. The transition metal-based approach allows for the generation of complexity through the simultaneous formation of C-F and C-C bond.
