Hot Topic Event - Pseudokinases as modulators of signal transduction in normal and cancer cells

3 December 2010, London, United Kingdom

Introduction

Pseudokinases are a protein family that constitute ~10% of the human kinome, characterized by the presence of a kinase-homology domain predicted to lack phosphoryl-transfer catalytic activity due to the absence of critical catalytic motifs. This Hot Topic Event will focus on pseudokinase classification and evolution, the molecular mechanisms by which pseudokinases regulate signal transduction, and how mutations affecting pseudokinases can cause human disease.