Operating a commercially viable chemical process requires a good chemical synthesis to start with, but is
also subject to the interplay of a myriad of important physical phenomena – heat transfer, mass transfer,
fluid flow, etc. which are traditionally the realm of the chemical engineer. An understanding of these scale-up
phenomena is crucial for the laboratory development of processes that will scale successfully.
This course presents an overview of these issues and examines their impact on process operation in the pilot
plant and beyond, including scale-up considerations for route selection, raw material charging, reaction steps,
workup, crystallization, product isolation, drying, etc. Common bench techniques for each of these steps are
contrasted to the safety and operability criteria for successful pilot plant operation. Numerous examples and
case histories are presented, along with tips and techniques for operators and experimenters. Heavy emphasis
is placed on process safety.
also subject to the interplay of a myriad of important physical phenomena – heat transfer, mass transfer,
fluid flow, etc. which are traditionally the realm of the chemical engineer. An understanding of these scale-up
phenomena is crucial for the laboratory development of processes that will scale successfully.
This course presents an overview of these issues and examines their impact on process operation in the pilot
plant and beyond, including scale-up considerations for route selection, raw material charging, reaction steps,
workup, crystallization, product isolation, drying, etc. Common bench techniques for each of these steps are
contrasted to the safety and operability criteria for successful pilot plant operation. Numerous examples and
case histories are presented, along with tips and techniques for operators and experimenters. Heavy emphasis
is placed on process safety.
