Welcome: from this page you can purchase selected video recordings from Biocatalysis Faraday Discussion that took place in London, 22 - 24 May 2024.
The sales window will be open 13 - 24 January 2025. During this time, click on the 'Book now' button above to purchase.
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Faraday Discussions are a unique conference format that priorities discussion. At a Faraday Discussion, the primary research papers written by the speakers are distributed to all participants before the meeting – ensuring that most of the meeting is devoted to discussing the latest research.
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Purchasing videos
Registration will provide you with access to the video recording of the original live conference for approximately five months. You will have have access to the pre-prints providing a full paper for each talk, and to the discussion sessions in that recording.
Go to the Registration section below to view the recordings that are available to purchase for this Faraday Discussion.
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Deadlines
This is a limited promotion and you will only be able to purchase recordings between 13 - 24 January 2025. If you choose to purchase a video recording from this Faraday, then you will be able to access the recording between 13 January 2024 - 13 May 2025. After 13 May the recording will expire and you will no longer be able to access it online. Don't miss this opportunity to experience parts of the science shared this Faraday Discussion for a fraction of the live registration fee.
Upon purchase, please allow up to 16 hours for access to the conference recording to be emailed to you.
Themes
Biocatalysis, a rapidly evolving field with increasing impact in synthesis, chemical manufacturing and medicine, is being transformed by advances in biophysical and computational techniques. It is expanding into new areas of chemistry, facilitated by de novo protein design, directed evolution, incorporation of new catalytic functionality into proteins, genetic data, developing spectroscopic and structural techniques, and informed by modelling, machine learning and artificial intelligence. The four themes of this Discussion united researchers working in different fields (for example synthetic biology, computational chemistry and mechanistic organic and organometallic chemistry) to improve our understanding of enzyme catalytic power with a view to engineering hybrid and artificial enzymes.
Enzyme evolution, engineering and design: mechanism and dynamics
This session focussed on understanding the effects of directed evolution on biocatalysts, the practical application of directed evolution, and understanding and overcoming the limitations of protein design and directed evolution. Specifically it includes: incorporation of simulation with protein design and directed evolution into protocols for biocatalyst development and optimization; integration of structurally detailed mechanistic models into biocatalyst design and engineering; predicting and evaluating effects of mutations in silico; biocatalyst discovery and optimization; tailoring of enzymes to specific reaction environments; creating de novo catalytic activities; role of the enzyme scaffold and scaffold engineering; entropy, enthalpy and activation heat capacity in thermoadaptation; biocatalyst screening; data mining and combining catalytic and biological (e.g. genetic and structural) data; stability-activity trade-offs; development of experimental and computational assays for biocatalysis activity.
Biocatalytic pathways, cascades, cells and systems
This session considered the compatibility of biocatalysts in natural (e.g. cellular) systems and how to integrate biocatalysts into practical processes, taking efficiency and environmental impact into account. Relevance to clean energy and achieving a net zero economy. Cleaner cofactor recycling for biocatalytic chemical synthesis. Whole cell cofactor regeneration. Sustainable synthesis. Environmental aspects. Engineering of metabolic pathways. Effects of cellular stress. Reaction optimization. Enzyme immobilization. Nanoreactors (e.g. lipid based). Biocatalytic retrosynthesis. Scale-up of processes. Opportunities to develop and optimise productive continuous flow processes in targeted catalytic reactions integrated with efficient product separation. Robustness of cascade/flow processes. In operando techniques for biocatalyst interrogation. Challenges of poorly water soluble substrates. Integrated chemo-enzymatic syntheses. Multiphase (liquid-liquid, solid-liquid) systems. Development of ‘toolboxes’ of biocatalysts primed for application and directed evolution.
Biocatalysis for industry, medicine and the circular economy
This session explored challenges in developing industrial applications, including the need to accelerate predictions of activity from the sequence; library screening; identification and optimization of enzyme stability for practical process application and optimal lifetime; comparison of all aspects of biocatalytic and equivalent chemocatalytic processes to quantify sustainability/economic differences; the development of process design methods for efficient implementation of the biocatalytic alternatives in industrial applications, and linking these effectively to chemocatalytic processes.
Artificial, biomimetic and hybrid enzymes
This session focussed on the development of hybrid biocatalysts, incorporating features of natural proteins. Specifically, it covered: the design, development and practical catalytic application of non-natural protein catalysts and biomimetic catalysts; comparison of artificial metalloprotein catalysts with natural metalloenzymes; control of reactivity and appropriate reaction conditions; metal recovery; optimization by chemogenetic methods to improve activity and selectivity of artificial metalloenzymes; links to protein design; scaffold and framework effects; directed evolution of protein biocatalysts containing unnatural amino acids; biomimetic organocatalysts.
